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Adaptive immunity. How can the immune system recognize so many different (previously unseen) insults? How does the immune system learn? How do B cells produce antibodies?. Antibody production after immunization. Irradiation prevents immune response.

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PowerPoint Slideshow about 'Adaptive immunity' - oren-fitzgerald


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adaptive immunity

Adaptive immunity

How can the immune system recognize so many different (previously unseen) insults?

How does the immune system learn?

How do B cells produce antibodies?

slide6

B cells

TC (Cytotoxic T cells)

TH (Helper T cells)

Also function in immune system

slide10

B cell activation

Each naïve B cell makes a single type of antibody with a unique binding specificity

Upon activation the naïve B cell proliferates and produces progeny that secrete that antibody

slide13

Primary response

Secondary response

slide14

Antibody action:Activation of Complement

Adaptive immunity (Innate immunity)

slide19

Antibody structure

Determines antibody class

slide21

Human heavy chain gene-segment pool

IgM IgG IgD IgE IgA

51 x 27 x 6 = 8262 possible H chain variable regions

40 x 5 = 200 possible k light chain variable regions

116 possible l chain variable regions

2.6 million possible

antigen binding sites from gene segment combinations

slide22

Human heavy chain gene-segment pool

51 x 27 x 6 = 8262 possible H chain variable regions

40 x 5 = 200 possible k light chain variable regions

116 possible l chain variable regions

2.6 million possible

antigen binding sites from gene segment combinations

slide26

Memory cells:

Somatic hypermutation in V regions

Class switching

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