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Sex on brain

Sex on brain. Sex on Brain European Research Group Lecture about sex differences of brain from a human perspective Ira RonitHeboldHaraldsen , GID section, Department of Neuro -psychiatry, Centre of Clinical Neuroscience, University of Oslo, National Hospital – Rikshospitalet – Oslo, Norway.

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Sex on brain

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  1. Sex on brain Sex on Brain European Research Group Lecture about sex differences of brain from a human perspective Ira RonitHeboldHaraldsen, GID section, Department of Neuro-psychiatry, Centre of Clinical Neuroscience, University of Oslo, National Hospital – Rikshospitalet – Oslo, Norway

  2. SOBER GroupSex on Brain European Research Group Effects of Gonadotropin Releasing Hormone Receptor blockage on brain development and behaviour in humans and animals

  3. SOBERSex on Brain European Research SOBER 1 = BIG 4 – Human treatment model – Clinical Research SOBER 2 = Animal model - Brain Biobank – March 2009 SOBER 3 = FMRI Models SOBER 4 = Human Genom Diagnostics

  4. Center for the Study of Human Cognition FRONTlundosloberkleyexecutivestudies Institute of Environmental Medicine (IMM)

  5. SOBER Board

  6. SOBER I – The Human ProjectEffects of Gonadotropin Releasing Hormone Receptor blockage on brain development and behaviour in humans • Andersson, Stein - Neuropsychologist • BjarkHalvorsen, Therese - Plastic surgeon, urologist • Cohen-Kettenis, Peggy – director • De Cuypere, Griet – director • Diseth, Trond - Child psychiatrist • Due Tønnesen, Paulina - Neuroradiologist • Fjell Anders – Controll group – director • Gross, Anniken - Gynecologist • Gulbrandsen, Kjersti - Psychiatric nurse • Haraldsen, Ira – director • Hellem, Frøydis – Psychologist • Heylens, Gunter - PhD • Kaspara, Solveig - Center coordinator • Kreukels, Baudewintje - Postdoc • Paap, Muirne – PhD • Richter-Appelt, Hertha – director • Nieder, Timo – PhD • Schreiner, Thomas- Endocrinologist • Tønseth, Kim Plastic - Surgeon • Walhovd, Kristine - Controll group – directors Peggy Cohen Kettenis

  7. SOBER 2An animal model Effects ofGonadotropin Releasing Hormone Receptor blockage on brain development and behaviour in sheep The introduction of a new animal model to evaluate sex specific consequences and mechanisms of a common hormone treatment strategy in man Brain biobank opens on the 28th of March 2009

  8. SOBER 2 - Cochno Farm - Oslo Kristine von Krogh, Hannah Harjen, DeborahKingsley, Stefan Suetterlin

  9. SOBER 3 - FMRI paradigm Model development for sex differences in adolescence Nordstrand og Tåsen skole Nina Tangstrøm, Haakon Engen

  10. Publications • 2008 in print • Hebold Haraldsen et al inTextbookofPsychiatry, Gyldendal, 2008 • Tønseth K, Haraldsen IR, Sex reassignment surgery, Den norskelegetidsskriften, 2008 • submitted in 2008 • HeboldHaraldsen*, I R. Casper, R. LH, FSH as predictors for cognitivefunction in normal middle-agedwomen, Psychoneuroendocrinology, submitted in 2008 • Paap M, Hebold Haraldsen I R, Sex specificcognitivesolutionstrategies in earlyonsetgenderidentitydisorderpatients, Neuropsychology, submitted in 2008 • 2009 to submitt first half year • Paap M, Hebold Haraldsen IR,, Prevalence, Diagnostics and comorbidity in Norwegianearlyonsetgenderidentitydisorderpatients, Psychiatric Research, 2009 • Hebold Haraldsen IR, Falch, J. cross sex patternof Ultrasound BMD measurements in in earlyonsetgenderidentitydisorderpatients, Endocrinology, 2009 • Endestad T, Melinder, A, Haraldsen, IR, A FMRI –model to discover sex differences in brain during adolescentdevelopment • al. et Hebold Haraldsen,Neurocognition in sheeptreated by prenatallyGnRHblockage, in work, expected in press 2009

  11. 2009 – 2014Understanding the time correlated phenomenon of puberty and sex differences of the brain • Behaviour and cognitive function of male and female animals/ humans, prior to treatment and after blockage of GnRHR • Structural changes of the brain between the sexes and the groups (cytoarchitecture, layer thickness and cell density • Neuronal/glial cell ratio, • Ccell proliferation and neuronal apoptosis • Degree of myelination • Synaptic distribution and integrity, using specific antibody • Architecture of dendritic tree and spine number • Gene expression and distribution of GnRH, ER alpha and beta, and AR receptors • Expression of hypothalamic oestrodiol receptors, GAD, GnRH, galanin, LH and FSH receptor immunreactivity and subsequent hormone secretion

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