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Research Opportunities in the Department of Otolaryngology-Head and Neck Surgery. Kibwei A. McKinney, MD Yu-Tung Wong, MD Scott Shadfar , MD. Outline. Funding opportunities Subspecialty Areas Clinical/Research Faculty Areas of Interest Examples. ENT Residency Application.

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research opportunities in the department of otolaryngology head and neck surgery

Research Opportunities in the Department of Otolaryngology-Head and Neck Surgery

Kibwei A. McKinney, MD

Yu-Tung Wong, MD

Scott Shadfar, MD

outline
Outline
  • Funding opportunities
  • Subspecialty Areas
  • Clinical/Research Faculty
    • Areas of Interest
  • Examples
ent residency application
ENT Residency Application
  • Step 1 USMLE Score
  • Medical School GPA
  • Extra-curricular Activities
  • Research
duration of research
Duration of Research
  • 2 months – Projects completed during the summerin between the 1st and 2nd yr
  • 1 year – Projects completed during a year off in between the 3rd and 4th years of medical school
grants funding opportunities
Grants/Funding Opportunities
  • 2 months – Research Training in Otolaryngology Program (8-12 weeks)
    • Application online at Carolina Medical Student Research Program website: www.med.unc.edu/rschofc/omsr/cmsrp.htm
    • Due Feb. 8th, 2010
  • 1 year - https://cgibd.med.unc.edu/omsr/oppor.php
    • Research Training in Otolaryngology
    • Doris Duke Clinical Fellowship Program
    • American Otologic Society Research Fellowship (T32)
    • Howard Hughes Medical Institute Training Fellowship
    • Holderness Fellowship (4 Yearly)
otolaryngology subspecialty areas
Otolaryngology Subspecialty Areas
  • Head and Neck Surgery (Cancer Research)
  • Otology/Neurotology
  • Facial Plastic Surgery
  • Rhinology/Sinus Surgery
  • Laryngology
  • Anterior Skull Base Surgery
  • Pediatric Otolaryngology
head and neck surgery
Head and Neck Surgery
  • Marion Couch, MD, Ph. D. – Cancer Cachexia
  • Neil Hayes, MD, MPH – Molecular pathogenesis of head and neck Cancers
  • Mark Weissler, MD – Outcomes Research in Head and Neck Cancer
  • Carol Shores, MD – EBV related Head and Neck Cancer in Lilongwe, Malawi
cancer cachexia
Cancer Cachexia
  • Loss of weight, muscle atrophy, catabolism associated with end-stage cancer
  • Significant cause of morbidity
cancer cachexia1
Cancer Cachexia
  • Historically thought to be mediated by increased energy expenditure by rapidly proliferating cancer cells
  • Increasing body of evidence attributing cachexia to pathophysiologic mechanisms at the cellular level
  • NF-κB – ubiquitous protein complex that controls DNA replication
    • When constitutively active, proper regulation does not occurcellularproliferationtumor
    • AlsoInflammation (possibly leading to cachexia)
resveratrol
Resveratrol
  • Potential NF-κB Inhibitor
  • Natural compound found in red wine, red grapes
  • Increased life span of nematode and short-lived fish
  • If good enough for the nematode, why not for us?
putting resveratrol to the test
Putting Resveratrol to the Test

Day 0 –Tumor Inoculation

Days 1-17 Document Cachexia/Treat with Resveratrol

Sacrifice and Harvest

outcomes
Outcomes
  • Tumor size
  • Body weight
  • Tissue NFκB levels
  • Cardiac echo readings
otology neurotology
Otology/Neurotology
  • Doug Fitzpatrick, Ph. D. – Preservation of residual hearing in cochlear implantation
  • Paul Manis, Ph. D. – Cellular mechanisms/neural networks of hearing
  • John Grose, Ph. D. – Age-Related decline in temporal processing
  • Craig Buchman, MD – Auditory Neuropathy, CI Outcomes
  • Oliver Adunka, MD – Electroacoustic Stimulation (EAS); Intraoperative electrophysiology
  • Joe Hall Ph. D./Emily Buss – Psychoacoustics
  • Joseph Roche, MD – SNHL and synaptic plasticity in Te1

Vestibulocochlear system of the Mongolian Gerbil; animal model used in electroacoustic studies

facial plastic and reconstructive surgery
Facial Plastic and Reconstructive Surgery
  • William Shockley, MD
  • Interests: Microtia repair, nasal defects and rhinoplasty, congenital anomalies
  • Clinical Outcomes Research
rhinology sinus surgery
Rhinology/Sinus Surgery
  • Julia Kimbel, Ph. D. – computational fluid dynamics, particle uptake deposition
  • Brent Senior, MD – MIPS Outcomes Research, Sleep Research
  • Charles Ebert, MD – QOL Outcomes for sinus surgery, Allergic Fungal Rhinosinusitis
allergic fungal rhinosinusitis
Allergic Fungal Rhinosinusitis
  • Disease process characterized by fungal proliferation, inflammation and deformation of the normal bony anatomy
  • Presents unilaterally in over 40% of patients
  • Hypothesis: These patients represent a genetic chimera with differential expression on the contralateral sides of the nose
  • Microarray analysis will be used to characterize these differences
laryngology
Laryngology
  • Robert Buckmire - Medical Robotic System for Laser Phonomicrosurgery
    • Joint venture with UNC/NC State Dept. of Biomedical Engineering
  • Image Guidance in

Laryngeal Surgery

laryngeal phonomicrosurgery
Laryngeal Phonomicrosurgery
  • Group of Complex surgical techniques that leverage the use of endoscopic tools
  • Surgical laser (CO2) under the control of a micromanipulator
  • Problem: poor ergonomics
laryngeal phonomicrosurgery1
Laryngeal Phonomicrosurgery
  • Hypotheses:
    • Different user interfaces may be advantageous in providing increased fine motor manipulation of the laser.
    • A trained robot may make more precise, uniform cuts than those made by a human
skull base surgery
Skull Base Surgery
  • Adam M. Zanation, MD – Molecular biology of sinonasal tumors, radioanatomic analysis of the pediatric skull base, outcomes research in endoscopic skull base surgery

PPF

PPF

GPC

GPC

Mucosa

Mucosa

pediatric otolaryngology
Pediatric Otolaryngology
  • Amelia Drake, MD
  • Austin Rose, MD
  • Carlton Zdanski, MD, FACS
  • Rose Payapilli, MD (resident) – clinical outcomes in patients with cochlear malformation after CI