Chapter 16: The Molecular Basis of Inheritance. Important Point:. If you are having trouble understanding lecture material: Try reading your text before attending lectures. And take the time to read it well!. Chromosomes consist of both DNA and Protein
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If you are having trouble
understanding lecture material:
Try reading your text
before attending lectures.
And take the time to read it well!
Hi, I’m Oswald Avery. I figured out that the transforming principle is DNA!
I did this by treating transforming principle with different enzymes, proteases, RNases, DNases… only DNase destroyed its activity
Avery, MacLeod, McCarty (1944)
Hi, I’m Theodosius Dobzhanky. I wrote: “Genetics and the Origin of Species” (1937)
Hi, I’m Colin M. MacLeod
Hi, I’m Maclyn McCarty
Colin M. MacLeod, Maclyn McCarty, Detlev Wulf Bronk, Theodosius Dobzhansky, and Wendell M. Stanley
Hi, I’m Detley Wulf Bronk. I asked, “Are aliens living among us” (really)
Hi, I’m Wendell M. Stanley. I crystalized (and then X-rayed) tobacco mosaic virus!
I made an important observation on the chemistry of DNA
Hershey & Chase, 1952
I took the first quality X-ray diffraction images of DNA, and am credited with sparking the interests of both Watson and Crick in the question of DNA’s structureMaurice Wilkins (1950)
Rosalind Franklin worked under me
Both daughter strands are laid down in the 5’ to 3’ direction
~100-2000 bases long, depending on species
Yes, difficult to read, but it is in your text!
Topoisomerase acts here
“During DNA replication, DNA polymerases proofread each nucleotide against its template as soon as it is added to the growing strand. Upon finding an incorrectly paired nucleotide, the polyerase removes the nucleotide and then resumes synthesis. (This action is similar to fixing a typing error by using the ‘delete’ key and then entering the correct letter.)” p. 305, Campbell & Reece (2005)
Erosion of ends
Telomere are sequences found on the ends of Eukaryotic DNA that are added on by an enzyme called telomerase
Telomeres erode so that genes don’t have to!