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What is CDNF? - PowerPoint PPT Presentation


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What is CDNF?. C onserved D opamine N eurotrophic F actor Growth factor known as a trophic factor Stimulates the growth of neurons. Recent In Vivo Studies. Scientists need rats that exhibit Parkinson’s-like symptoms Administer 6-Hydroxydopamine (6-OHDA) Kills off Dopaminergic neurons

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what is cdnf
What is CDNF?
  • Conserved Dopamine Neurotrophic Factor
  • Growth factor known as a trophic factor
  • Stimulates the growth of neurons
recent in vivo studies
Recent In Vivo Studies
  • Scientists need rats that exhibit Parkinson’s-like symptoms
    • Administer 6-Hydroxydopamine (6-OHDA)
      • Kills off Dopaminergic neurons
      • Induces Parkinson’s-like symptoms

6-hydroxydopamine

L-Dopa

Dopamine

important lab findings
Important Lab Findings
  • CDNF was injected into Striatum of rats before 6-OHDA
    • CDNF prevented PD symptoms from occurring
  • Rats were treated to express PD symptoms
    • Injected with 6-OHDA
    • 4 weeks later, treated with CDNF
      • Neuron function and viability was restored
screening patients
Screening Patients
  • Adequate patient response to L-Dopa
    • Indicates DA neurons are degraded but treatable
  • No effect of L-Dopa
    • Indicates that DA neurons have degraded completely

http://www.physorg.com/news/2010-10-parkinson-disease-closer.html

benefits in human trials
Benefits in human trials
  • CDNF has a “protective” effect
    • Prevents neuron degradation
  • CDNF can restore up to 98% function
    • Promoting DNA replication
  • Can be administered through lumbar puncture
    • Out-patient procedure
    • Anaesthetized for comfort
    • Use Mannitol to penetrate the Blood-Brain-Barrier