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Circadian rhythms and aging . Julia Tong RE|NOUS March 03, 2014 General Meeting III . Outline. What is circadian rhythms (CR)? How does CR pertain to aging? How does CR affect AD? . Circadian Rhythms . Body go through cycles each day to maintain homeostasis.

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circadian rhythms and aging

Circadian rhythms and aging

Julia Tong

RE|NOUS

March 03, 2014

General Meeting III

outline
Outline
  • What is circadian rhythms (CR)?
  • How does CR pertain to aging?
  • How does CR affect AD?
circadian rhythms
Circadian Rhythms
  • Body go through cycles each day to maintain homeostasis.
  • Every cell in your body has a rhythm (internal clock) and the output oscillates according to the environment.
  • Examples:
    • Blood pressure
    • Melatonin levels
    • Liver enzymes
    • Body temperature
circadian rhythms ii
Circadian Rhythms II
  • Think of bodily functions and secretions are clocks
  • SCN is the central clock
    • It is the site of the biological clock
    • Without it, the body is arrhythmic
    • Animal dies
circadian rhythms and aging1
Circadian Rhythms and Aging
  • Aging changes the human circadian behavior
  • Older humans/animals circadian activity cycle shortens with age.
      • Think about your own circadian (sleep/wake) cycle!
  • Numerous studies have shown CR interconnected with longevity and age related changes in rhythms.
  • No clear mechanistic or molecular factors identified yet.
paper s conclusion
Paper’s Conclusion
  • SIRT1 regulate central circadian control to determine period, acitivty level, and adjust to reentrainment.
  • SIRT1 directly activates Bmal1 in SCN
    • Increasing expression of other clock genes
  • Aged mice have low SIRT1 and BMAL1
    • Inability to adjust to abrupt light adaptation
  • Overexpressing brain SIRT1 are partially protected
    • Reversitol
    • Low fat diet
cr and alzheimer s disease
CR and Alzheimer’s Disease
  • AD pts. have disrupted CR
  • Sundowning: agitated during evening
    • Never get a complete night sleep, issues with sleep/wake cycle.
    • Sleep disturbances have devastating effects that leaves pts. Institutionalize.
  • Studies show that AD pts have disturbances in CR and sundowning is related to phase delay of body temperature
slow aging with a good clock
Slow aging with a good clock
  • Treat age related diseases by enhancing Circadian Function.
    • SIRT1 to brain
    • Other drugs along pathway
  • Treatment for AD patients, ease sundowning
    • Adjust patients to the Light/dark cycle
    • Understand patient’s CR
      • Sync them to environment
        • Bright light during morning
        • Melatonin at night