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Research update

10/14/2010 Andrej Mosat, LPPD, UIC. Research update. Cyclosporine A Paper. 1. Paper for Journal of Theoretical Biology on Cyclosporine A delivery in a Rat and a Human. Main Points.

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Research update

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  1. 10/14/2010 Andrej Mosat, LPPD, UIC Research update

  2. Cyclosporine A Paper • 1. Paper for Journal of Theoretical Biology on Cyclosporine A delivery in a Rat and a Human

  3. Main Points • 1. All organs in a mammalian body are interconnected. Closed vasculature multicompartmental model of arbitrary complexity can simulate novel drug's biodistribution reliably • 2. Simple first order model as a set of partial differential equations leads to more insight than complicated models with curve fitting. • 3. A case study supporting the two solution approaches will be presented on Cyclosporine A IV bolus injection in Sprague Dawley rats.

  4. Methods • We show two solution approaches to the network and kinetic inversion problem: • a.) numerically solving a networked system of DAEs by "DASSL" • b.) numerically solving the system of PDE`s by "the sensitivity method“ • - automatic equation generator • - DAE solver • - Analytical solution for systems of DAEs cannot be obtained in general

  5. Case study • Rat, bolus IV Injection vs. • Human, bolus IV Injection Challenges: Unclear measurement data. Tail ? Different Proteins in Rats/Humans

  6. Figures

  7. Rat network = Human network

  8. First principle models

  9. Concentration Profiles Rat/Human

  10. Mass balance "R:\matlab\from Eric\Cyclosporin A\20101030-FIG-CyA-Mass.jpg"

  11. Blood/Plasma "R:\matlab\from Eric\Cyclosporin A\20101030-FIG-CyA-Mass.jpg"

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