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The Mutability and Repair of DNA

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The Mutability and Repair of DNA - PowerPoint PPT Presentation


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The Mutability and Repair of DNA. REPLICATION ERRRORS AND THEIR REPAIR. The nature of mutations. Transitions. Transversions. Some replication errors escape proofreading. Mismatch repair removes errors that escape proofreading. Structure of MutS and DNA

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Presentation Transcript
slide1
The Mutability and Repair of DNA

REPLICATION ERRRORS AND THEIR REPAIR

The nature of mutations

Transitions

Transversions

slide4
Structure of MutS and DNA

(MutS recognizing mismatches from the distortion they cause)

slide8
DNA DAMAGE

DNA undergoes damage spontaneously from hydrolysis and deamination

slide13
Bruce N. Ames

Professor of the Graduate School Division of Biochemistry and Molecular Biology, UC Berkeley

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How is an altered base detected within the context of the double-helix?

The recognition of an unusual nucleotide in DNA by base-flipping of glycosylase

slide23
Recombination repair DNA breaks by retrieving sequence information from undamaged DNA

Double-Strand Breaks are Efficiently Repaired

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