slide1 n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
NPY Inhibition of Catecholamine Release PowerPoint Presentation
Download Presentation
NPY Inhibition of Catecholamine Release

Loading in 2 Seconds...

play fullscreen
1 / 2

NPY Inhibition of Catecholamine Release - PowerPoint PPT Presentation


  • 120 Views
  • Uploaded on

NPY Inhibition of Catecholamine Release. SIGMA-ALDRICH. NPY Inhibition of Catecholamine Release

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'NPY Inhibition of Catecholamine Release' - odeda


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
slide2

NPY Inhibition of Catecholamine Release

Catecholamine synthesis and release are two separate but related processes that influence the level of catecholaminergic neurotransmission. Neuropeptide Y (NPY) is a 36 amino acid peptide that is highly homologous to peptide YY (PYY). NPY exerts its various biological effects through at least six classes of receptors, designated Y1, Y2, Y3, Y4, Y5, and Y6. It has been demonstrated that NPY inhibits catecholamine synthesis via the Y3 receptor subtype, in contrast to the Y2 subtype that mediates inhibition of catecholamine release. Although inhibition of both synthesis and release by these receptor subtypes is via inhibition of Ca2+ entry, the two processes are associated with actions on distinct Ca2+ channel subtypes. Inhibition of L-type Ca2+ channels mediates inhibition of catecholamine synthesis, while inhibition of N-type Ca2+ channels inhibits catecholamine release.

References

McCullough, L.A., et al., Neuropeptide Y receptors involved in calcium channel regulation in PC12 cells. Regul. Pept., 75-76, 101-107 (1998).

Cavadas, C., et al., NPY regulates catecholamine secretion from human adrenal chromaffin cells. J. Clin. Endocrinol Metab., 86, 5956-5963 (2001).