Antiplatelets. Clopidogrel vs. aspirin. Overview . When should clopidogrel be prescribed instead of aspirin? What is meant by ‘intolerance to aspirin’? Does clopidogrel cause fewer GI adverse effects than aspirin? How can the risk of GI adverse effects of aspirin or clopidogrel be reduced?
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Clopidogrel vs. aspirin
“….the Committee concluded that clopidogrel was likely to be at least as effective as aspirin. Therefore, for people with recent MI or symptomatic PAD who are intolerant of aspirin, clopidogrel was an appropriate alternative.
….Genuine aspirin intolerance, defined by hypersensitivity reactions or severe dyspepsia, should be differentiated from mild dyspeptic symptoms, which are common.”
0.7% (95%CI 0.0 to 2.0%)
8.6% (95%CI 4.1 to 13.1%)
Do clopidogrel and PPIs interact?MHRA/CHM. Drug Safety Update. Volume 2, issue 12. July 2009www.npci.org.uk/blog/?p=354; www.npci.org.uk/blog/?p=372
Update on clopidogrel and PPIswww.npci.org.uk/blog/?p=1263MeReC Monthly No.27. June 2010