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Multivitamin Dissolution In a Vinegar Bath

Multivitamin Dissolution In a Vinegar Bath. Brooke Coffey Undergraduate Student of Biology Tennessee Technological University Cookeville, TN 38505 20 November 2006. Introduction. American dietary trend is progressively diverging from proper nutrition.

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Multivitamin Dissolution In a Vinegar Bath

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  1. Multivitamin Dissolution In a Vinegar Bath Brooke Coffey Undergraduate Student of Biology Tennessee Technological University Cookeville, TN 38505 20 November 2006

  2. Introduction • American dietary trend is progressively diverging from proper nutrition. • Today’s RDA values date back to 1968 (Smith 2005) • B12 and Folic Acid • U.S. & Canada Fortify Foods (Oakley 2004) • Homocysteine reduction (Wald 2002) • Vitamin C (Shapiro et al. 1983) • Vitamin D (Johnson and Kimlin 2006)

  3. Introduction • Vitamin E • In vascular disease (Brown and Crowley 2005) • Deficiency symptoms (Higdon 2004) • Vitamin K (Environmental Nutrition 2006) • In blood clotting • bone development

  4. Introduction • Many people rely on the multivitamin to provide micronutrients • The vitamin may not disintegrate in the stomach • Intestinal absorption is beyond the scope of this experiment. • Hypothesis – multivitamin mass is directly proportional to disintegration time. • Null Hypothesis– mass is not directly proportional to disintegration time.

  5. Methods and Materials • ConsumerLabs home test modified method • 125mL portion vinegar • 125mL portion of distilled water • Three brands of multivitamin • Erlenmeyer flask with stopper, and thermometer. • Heating Mantle • Stopwatch

  6. Materials

  7. Materials

  8. Table 1

  9. Figure 1 Figure 1 comparing multivitamin mass against disintegration time in seconds

  10. Results • Multivitamin disintegration times were not correlated in any way with mass. • All pellets weighed in within .05g of 1.5g • Pellets of the same type took a similar time per environment. • Pellets of different types took vastly different times to disintegrate.

  11. Summary & Conclusions • Centrum and Equate both dissolve in under 400 seconds. • OneSource takes more than 1200 seconds. • Neither pH nor heat affected the disintegration time for a brand.

  12. Conclusion • Multivitamin mass is not directly proportional to disintegration time. • Further testing is needed to determine the significance of continuous stabilized motion as force acting in disintegration. • Additional research is needed covering the contributions of ingredient quantities, and pellet coating or compaction methods to multivitamin pellet disintegration.

  13. Literature Cited • Brown GB, Crowley J. 2005. Is there any hope for vitamin E? JAMA 293:1387-90. • ConsumerLabs.com. 2006. ConsumerLab.com "Home Test" for Disintegration. http://www.consumerlab.com/results/hometest.asp • Higdon, Jane Ph.D. 2004. Linus Pauling Institute. Oregon State University http://lpi.oregonstate.edu/infocenter/vitamins/vitaminE/ • Johnson, Mary Ann PhD., and Kimlin, Michael G. PhD. 2006. Vitamin D, Ageing, and the 2005 Dietary Guidelines for Americans. Nutrition Reviews 64:410-421. • McKee, Courtney H. 2005. The Effect of Pill Type on Disintegration Rate and Process. California State Science Fair. Project S0515. http://www.usc.edu/CSSF/History/2005/Projects • Oakley, Godfrey P. Jr. MD. 2004. Oral Synthetic Folic Acid and Vitamin B12 Supplements Work – If One Consumes Them. Nutrition Reviews 62:22-26. • Shapiro, Leona R., Samuels, Sarah., Breslow, Lester., and Camacho, Terry. 1983. Patterns of Vitamin C Intake from Food and Supplements. AJPH 73:773-778 • Smith, Susan Male M.A. 2005. Vitamins, Minerals, and Multis: EN Tests Your Suppliment IQ. Environmental Nutrition 28:5-6 • 2006. What’s So Special About Vitamin K? Bone Builder, Arthritis Aid. Environmental Nutrition p.7.

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