a near real time surveillance program for prrs in iowa united states n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
A near real-time surveillance program for PRRS in Iowa, United States PowerPoint Presentation
Download Presentation
A near real-time surveillance program for PRRS in Iowa, United States

Loading in 2 Seconds...

play fullscreen
1 / 51

A near real-time surveillance program for PRRS in Iowa, United States - PowerPoint PPT Presentation


  • 120 Views
  • Uploaded on

University of California, Davis. A near real-time surveillance program for PRRS in Iowa, United States. Perez AM, Polson D, Mueller K, Cano JP, Brito B, Mondaca E, Whedbee Z, Main R. University of California in Davis (Perez, Brito, Whedbee )

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'A near real-time surveillance program for PRRS in Iowa, United States' - nubia


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
a near real time surveillance program for prrs in iowa united states

University of California, Davis

A near real-time surveillance program for PRRS in Iowa, United States

Perez AM, Polson D, Mueller K, Cano JP, Brito B, Mondaca E, Whedbee Z, Main R

University of California in Davis (Perez, Brito, Whedbee)

Iowa State University (Mueller, Main)

BoehringerIngelheimVetmedica Inc (Polson, Cano, Mondaca)

GEOVET Conference 2013

21-23 August

London, UK

slide2

A near real-time surveillance program for PRRS in Iowa, United States

  • Relevant Context
  • Prerequisite Culture
  • Necessary Collaborations
  • Required Tools
slide3

A near real-time surveillance program for PRRS in Iowa, United States

  • Relevant Context
  • Prerequisite Culture
  • Necessary Collaborations
  • Required Tools
porcine reproductive and respiratory syndrome prrs virus
Porcine Reproductive and Respiratory Syndrome (PRRS) virus
  • Enveloped RNA virus - order Nidovirus, family Arteriviridae, genus Arterivirus.
  • Causes reproductive failure of sows and respiratory problems of piglets and growing pigs
  • The single most important swine disease in North America
  • Cost for the US swine industry : $664 million USD/year*
  • Difficult to control
    • TRANSMISSION
    • PERSISTENCE
    • GENETIC DIVERSITY- heterologous protection
    • MULTIPLE CLINICAL PRESENTATIONS
  • Swine industry efforts to control PRRS: ARC&E projects
what makes a problem wicked
What makes a problem “wicked”?

“The kinds of problems that planners deal with…are inherently different from the problems that scientists and perhaps some classes of engineers deal with. Planning problems are inherently wicked.”

Rittel & Webber (1973)

context

A near real-time surveillance program for PRRS in Iowa, United States

Context:
  • Science is good…
  • …and institutional-scale science has & continues to make very valuable contributions to its business & professional constituencies
  • …but institutional-scale science has limitations…
  • Institutional-scale science can tell us:
    • What HAS happened (retrospective, observational)
    • What CAN happen, given a specific and defined condition set (experimental)
context1

A near real-time surveillance program for PRRS in Iowa, United States

Context:
  • We need to complementinstitutional-scale (cross-sectional/static) science with industrial-scale (operational/dynamic) science…

…science that can tell us what DOES happen…

…every time it happens…

…that helps us understand why it happens…

…what we can do about it…

…and measure if what we did was valuable.

key target questions

A near real-time surveillance program for PRRS in Iowa, United States

Key target questions:
  • Am I negative or positive?
  • Am I stable or unstable?
  • Is this resident or non-resident virus?
    • How did it get here?
    • Where did it come from?
  • Is this a previously existing or a new variant?
    • Where did it start?
    • When did it start?
    • How did it start?
key target questions1

A near real-time surveillance program for PRRS in Iowa, United States

Key target questions:
  • Is what I’ve been doing working?
  • Would something else work better?
  • Am I at lower/same/higher risk today compared to yesterday?
  • Am I progressing towards or away from my goals of [_____]?
  • Why am I progressing towards or away from my goal(s)?
  • What can I do to fix/improve what I’m doing today?
slide12

A near real-time surveillance program for PRRS in Iowa, United States

If PRRSv really costs us “$664,000,000” per year, maybe it’s well worth it to us all to actively work together using all the tools & weapons we have available today to manage it in a coordinated collaborative effort.

slide13

A near real-time surveillance program for PRRS in Iowa, United States

2009:

10+1 total projects

slide14

A near real-time surveillance program for PRRS in Iowa, United States

2013:

25+4 total projects

slide15

A near real-time surveillance program for PRRS in Iowa, United States

  • Relevant Context
  • Prerequisite Culture
  • Necessary Collaborations
  • Required Tools
area regional control elimination arc e is
Area-Regional Control & Elimination (ARC&E) is…

…producers & veterinarians working together with their neighbors and business partners so that together they achieve greater sustained improvement in health and productivity in their neighborhood than any one can achieve on their own.

A near real-time surveillance program for PRRS in Iowa, United States

the golden prrs rule
The Golden (PRRS) Rule

“DoTRANSMITunto

your neighbor

as you would have

your neighbor

doTRANSMITunto you.”

slide18

A near real-time surveillance program for PRRS in Iowa, United States

Better

Together

Be BetterTogether

slide19

A near real-time surveillance program for PRRS in Iowa, United States

  • Relevant Context
  • Prerequisite Culture
  • Necessary Collaborations
  • Required Tools
slide20

Primary Collaborators:

ISU,

UC-Davis,

FAZD-DHS,

CFSPH, Progressus Ltd,

BIVI

Veterinarians Across U.S. Submitting Cases to their VDL Service Providers

Submitters indicate the inclusion of a submission (case) in a specific regional disease monitoring effort (project) on the diagnostic laboratory submission form

Case Submission

All Dx Results

Case Submission

All Dx Results

Case Submission

All Dx Results

VDL LIMS (e.g. UMN)

VDL LIMS (e.g. SDSU)

VDL LIMS (e.g. ISU)

Pathogen Specific

Dx Data Only

(Pushed)

Pathogen Specific

Dx Data Only

Pathogen Specific

Dx Data Only

Secure Animal Health Diagnostic Database

(SAHDD)

Based on: HIMS® Platform

(Web-Based, Password Protected, Viewable, Sortable)

(Pushed)

(Pushed)

Rhapsody

AgConnect®

Interpreted Diagnostic Data

Pathogen Specific

Dx Data Only

View only

(Pushed)

Permissioned

Animal Health

Officials

(Pushed)

Interpreted Diagnostic Data

Rules-based decisions used to update

Initially = System Administrator

Goal =Automation

(Pushed)

Interpreted Diagnostic Data

(Pushed)

Antigenic Cartography Analysis

System

Sequence Data

PADRAP Data

Disease BioPortal®

Real-time disease analysis and mapping

(Web-based & Password Protected)

PADRAP®

(Web-based & Password Protected)

Cartographs

Dynamic Risk Data

View Data/Reports

View only

Input Surveys

PermissionedBioPortal® Users

Permissioned

PADRAPUsers

slide21

A near real-time surveillance program for PRRS in Iowa, United States

  • Relevant Context
  • Prerequisite Culture
  • Necessary Collaborations
  • Required Tools
design specifications

A near real-time surveillance program for PRRS in Iowa, United States

Design Specifications:
  • Operations (transactions) user funded
    • Sampling, logistics, testing, data-management, analytics
  • Cost-efficient to implement & inexpensive to operate
  • Convenient & easy to do perpetually
    • Standardized materials, tools, methods & processes , definitions & metrics, analytics & interpretation
design specifications1

A near real-time surveillance program for PRRS in Iowa, United States

Design Specifications:
  • Automated everywhere possible
  • Interfaced / integrated with all best-in-class tools and methods
  • Near-real-time results & interpretation
  • Pre-defined “best-practice” contingencies
design specifications2

A near real-time surveillance program for PRRS in Iowa, United States

Design Specifications:
  • Supports well-informed decision-making
    • Intra-Enterprise
      • in-process / execution-level
      • Management oversight / process-level
    • Inter-Enterprise
      • Within Areas & Regions
      • Among Areas & Regions
    • Policymakers
  • Supports rigorous research & effective learning
  • Effective training/education & support structure
  • Broad & deep support by served constituents and leaders
the bioportal
The BioPortal
  • Collect
  • Compile
  • Organize
  • Analyze
  • Share
  • Use data
  • Web-based health management system
  • To support “local” decision-making for PRRS management and contingent action execution by veterinary practitioners and farmers
  • To support “regional” monitoring of progress towards area- and network-based PRRS management

Objectives

how did it start
How did it start?

January 2010

CADMS/UC-Davis & BoehringerIngelheim collaboration agreement

Phases:

1.- Adaptation and implementation

Adapt Disease BioPortal platform to manage PRRS cases and become adopted as a standard tool for PRRS ARC&E project use and epidemiological analysis in the U.S. swine industry

2.- Improvement and expansion

Increase capabilities of Disease BioPortal to be employed as a surveillance and epidemiological analysis tool for swine diseases

collaborators
Collaborators
  • Center for Animal Disease Modeling and Surveillance -University of California-Davis (CADMS)
  • BoehringerIngelheimVetmedica
  • Iowa State University Veterinary Diagnostic Laboratory (ISU-VDL)
  • Production Animal Disease Risk Assessment Program (PADRAP)
  • SE IA PRRS ARC Project Coordinator
slide28

BioPortal Tools- PRRS site

http://fmdbioportal.ucdavis.edu/

slide30

Is it a new isolate to the herd or system?

Where did it most likely come from?

New isolate to the system (3%)

current work in progress
Current work in progress
    • The system is being piloted by participating farms in a South-East Iowa PRRS Area Control Project
      • 45 producers-large and small
      • 410 sites enrolled ~1,000,000 pigs
      • Local and regional consulting veterinarians
  • Development and improvement of the PRRS BioPortal tailored to PRRS and the swine industry
  • Platform for data transfer ISU-VDL –to- BioPortal
  • Definitions and standards for data management
what s next
What’s next?
  • Interpretation algorithms development & automation
    • Case result
    • Site status
    • Site classification
  • Development phases
    • Bioportal enhancements (e.g., producer/veterinarian operational health management tools)
    • Interfaces with other systems (e.g., VDL LIMS, PADRAP)
  • Broad adoption
    • Systems
    • Practices
    • ARC&E projects
    • VDL’s
  • Research leverage
slide34

Primary Collaborators:

ISU,

UC-Davis,

FAZD-DHS,

CFSPH, Progressus Ltd,

BIVI

Veterinarians Across U.S. Submitting Cases to their VDL Service Providers

Submitters indicate the inclusion of a submission (case) in a specific regional disease monitoring effort (project) on the diagnostic laboratory submission form

Case Submission

All Dx Results

Case Submission

All Dx Results

Case Submission

All Dx Results

VDL LIMS (e.g. UMN)

VDL LIMS (e.g. SDSU)

VDL LIMS (e.g. ISU)

Pathogen Specific

Dx Data Only

(Pushed)

Pathogen Specific

Dx Data Only

Pathogen Specific

Dx Data Only

Secure Animal Health Diagnostic Database

(SAHDD)

Based on: HIMS® Platform

(Web-Based, Password Protected, Viewable, Sortable)

(Pushed)

(Pushed)

Rhapsody

AgConnect®

Interpreted Diagnostic Data

Pathogen Specific

Dx Data Only

View only

(Pushed)

Permissioned

Animal Health

Officials

(Pushed)

Interpreted Diagnostic Data

Rules-based decisions used to update

Initially = System Administrator

Goal =Automation

(Pushed)

Interpreted Diagnostic Data

(Pushed)

Antigenic Cartography Analysis

System

Sequence Data

PADRAP Data

Disease BioPortal®

Real-time disease analysis and mapping

(Web-based & Password Protected)

PADRAP®

(Web-based & Password Protected)

Cartographs

Dynamic Risk Data

View Data/Reports

View only

Input Surveys

PermissionedBioPortal® Users

Permissioned

PADRAPUsers

slide38

Primary Collaborators:

ISU,

UC-Davis,

FAZD-DHS,

CFSPH, Progressus Ltd,

BIVI

Veterinarians Across U.S. Submitting Cases to their VDL Service Providers

Submitters indicate the inclusion of a submission (case) in a specific regional disease monitoring effort (project) on the diagnostic laboratory submission form

Case Submission

All Dx Results

Case Submission

All Dx Results

Case Submission

All Dx Results

VDL LIMS (e.g. UMN)

VDL LIMS (e.g. SDSU)

VDL LIMS (e.g. ISU)

Pathogen Specific

Dx Data Only

(Pushed)

Pathogen Specific

Dx Data Only

Pathogen Specific

Dx Data Only

Secure Animal Health Diagnostic Database

(SAHDD)

Based on: HIMS® Platform

(Web-Based, Password Protected, Viewable, Sortable)

(Pushed)

(Pushed)

Rhapsody

AgConnect®

Interpreted Diagnostic Data

Pathogen Specific

Dx Data Only

View only

(Pushed)

Permissioned

Animal Health

Officials

(Pushed)

Interpreted Diagnostic Data

Rules-based decisions used to update

Initially = System Administrator

Goal =Automation

(Pushed)

Interpreted Diagnostic Data

(Pushed)

Antigenic Cartography Analysis

System

Sequence Data

PADRAP Data

Disease BioPortal®

Real-time disease analysis and mapping

(Web-based & Password Protected)

PADRAP®

(Web-based & Password Protected)

Cartographs

Dynamic Risk Data

View Data/Reports

View only

Input Surveys

PermissionedBioPortal® Users

Permissioned

PADRAPUsers

slide42

Primary Collaborators:

ISU,

UC-Davis,

FAZD-DHS,

CFSPH, Progressus Ltd,

BIVI

Veterinarians Across U.S. Submitting Cases to their VDL Service Providers

Submitters indicate the inclusion of a submission (case) in a specific regional disease monitoring effort (project) on the diagnostic laboratory submission form

Case Submission

All Dx Results

Case Submission

All Dx Results

Case Submission

All Dx Results

VDL LIMS (e.g. UMN)

VDL LIMS (e.g. SDSU)

VDL LIMS (e.g. ISU)

Pathogen Specific

Dx Data Only

(Pushed)

Pathogen Specific

Dx Data Only

Pathogen Specific

Dx Data Only

Secure Animal Health Diagnostic Database

(SAHDD)

Based on: HIMS® Platform

(Web-Based, Password Protected, Viewable, Sortable)

(Pushed)

(Pushed)

Rhapsody

AgConnect®

Interpreted Diagnostic Data

Pathogen Specific

Dx Data Only

View only

(Pushed)

Permissioned

Animal Health

Officials

(Pushed)

Interpreted Diagnostic Data

Rules-based decisions used to update

Initially = System Administrator

Goal =Automation

(Pushed)

Interpreted Diagnostic Data

(Pushed)

Antigenic Cartography Analysis

System

Sequence Data

PADRAP Data

Disease BioPortal®

Real-time disease analysis and mapping

(Web-based & Password Protected)

PADRAP®

(Web-based & Password Protected)

Cartographs

Dynamic Risk Data

View Data/Reports

View only

Input Surveys

PermissionedBioPortal® Users

Permissioned

PADRAPUsers

conclusions
Conclusions
  • The approach here represents a multi-institutional effort with direct impact in the control of, arguably, the most important disease of swine in the United States. The project may be easily scaled-up to include larger areas as well as other diseases.
  • Data collection and organization is the most significant challenge. It can be overcome by automating processes and strategizing resources
  • This tool will demonstrate its value when applied in control interventions, reducing incidence/prevalence
slide49

Acknowledgments

  • Swine practitioners and producers
  • ISU Veterinary Diagnostic Laboratory
  • BIVI Health Management Center
  • PADRAP
  • SE IA PRRS ARC Project Coordinator