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GPCR Edition – Week 1 - PowerPoint PPT Presentation


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GPCR Edition – Week 1. Amino Acid Structure. Amino Acids: Misc. GPCR Structure. Chemical Interactions. Protein Secondary & Tertiary Structure. Potpourri. 100. 100. 100. 100. 100. 100. 200. 200. 200. 200. 200. 200. 300. 300. 300. 300. 300. 300. 400. 400. 400. 400. 400.

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Presentation Transcript
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Amino Acid Structure

Amino Acids: Misc.

GPCR Structure

Chemical Interactions

Protein Secondary & Tertiary Structure

Potpourri

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The amino acid arginine has this grouping of amino acids, along with lycine and histidine (if the pH is just right)

Positively charged

slide11

“alpha” refers to this element that is covalently bonded to an amino group, a carboxyl group, a hydrogen, and a side chain

Carbon

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GPCRs are embedded into a membrane bilayer composed of this type of biological molecule

Phospholipid

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GPCRs are very difficult to crystallize and often times have crystallization “handles” fused to them. This one is similar to what we used in our experiment.

T4 Lysozyme

slide16

This class of GPCRs has a large extracellular domain with a “venus-flytrap” structure where ligands bind

Class C

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Class A GPCRs have this conserved sequence motif of three amino acids that mediates coupling to G proteins

DRY, Asp-Arg-Tyr

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The attraction of a cation to an anion is referred to as this type of non-covalent chemical interaction

Ionic/Electrostatic

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This non-covalent is what drives non-polar amino acids to orient themselves towards the interior of a protein and away from water

Hydrophobic Effect

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A peptide bond is a covalent chemical interaction between the amino group of one amino acid and this group of the other

Carboxyl

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DAILY DOUBLE

Hydrogen bonding between the carbonyl oxygen and amino group hydrogen of two amino acids 4 residues apart stabilizes this type of structure

Alpha helix

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This is the simplest arrangement a polypeptide chain can make in terms of secondary structure

Alpha Helix

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This amino acid’s rigidity results in its low probability of being found in an alpha helix

Proline

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The partial positive and negative charge of an alpha helix N- and C-terminus, respectively, is referred to as this

Helix Dipole

slide26

This is the name of the chart that measures the probability of particular psi and phi angles to be found in secondary structure

Ramachandran

slide27

This protein structural motif is named after a common architectural design found in the Hellenic Republic

Greek Key Motif

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This level of protein structure is the arrangement of 2 or more separate polypeptide chains (subunits)

Quaternary

slide30

The functional and folded structure of a protein in its normal environment is known as this

Native conformation

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The formation of a peptide bond between two amino acids results in the creation of this molecule, which is why the reaction is called condensation

Water

slide32

Which university is the only one in NCAA history to hold the national title in both basketball and football?

University of Florida