Theory on the Psychosomatic and Organic Disease By Franco Bucca MD

1. Theory on the Psychosomatic and Organic DiseaseByFranco Bucca MD

2. Highly Traumatic and Conflictual Event • Conflicts • Mind experience • Mind and brain • The whole mind

3. Highly Traumatic and Conflictual Event Life condition or, give rise to a “conflict” at the decisional and organizational Level of Ego, this conflict is transmitted in all its drammaticity essence and strength to the Mind.

4. Conflicts The mind can not objectify negative input and The “Conflict” that has became Intrapsychic places Itself in the Mind Subconscius.

5. Mind experiences Have a unitary composition and the unity is specific for each type of experience, has been defined “Psychones”. Each Psychones is bound in unitary way to specific Dendron. (Eccles and Popper)

6. Mind and Brain The connection represents the Mind-Brain interaction in accordance with Quantum Physics.

7. The Whole Mind The whole mind’s world and the experiences i.e. the combination of the inner and external sensitiveness (Eccles’s and Popper’s World n°2), Is formed by a whole of “unitary mind’s event or elementary ultra-micro-granule called “ Psychones, and there is one Psychones for each Dendron, which envelops as a glove the single Dendron. Therefore is specific and exclusive connection. Structure of a dendronized polymer

8. Bucca Supports: • The hypothesis of the Mind-Brain interaction in accordance with the • Quantum Physics, and on the basis of the experimental results, foresees • Not Physical Event (Popper’s world n°2) in our specific case • “intrapsychic conflict energy”, is bound and can be transmitted • to the brain, where it is recorded as “Neuro Event” (Popper’s world n°1). • That is the Psycone that grows carrier of the energy flow which • regulates the interaction; • Mind’s Conflictual Event- Dendron’s (Cortical) Nervous Event.

9. Conflictual and Cortical’s Nervous Event We know on the basis of the experimental trials and results of the search, how “Intention“ defines a measurable Event Nervous Cortical noteworthy with the modern Neuroimaging , so we underline that, if may be recorded a thought an intention at cortical level, all the more reason why it may be recorder. An overstimulation a particular severe energy flow, as precisely as “Mind’s conflictual Event, bound to an acute or chronic suffering nucleus which causes “Cortical’s Nervous Event”. Example

11. The Flow Energy Shall Flow on the Dendron Mind’s Conflictual Event which has altered Psycone as carrier, it would define an electric discharge of particular intensity at level of the Cortical’s Pyramidal dendron, Which should feel (Physical Nervous Event), and main effect ( neurochemical response) should be an alteration of the Exocytosis of Neurotransmission either at the level of Cortical Areas or Sub-cortical Centres. Moreover it will cause repercussions on the Cortical functions, on the Neuroglia functions, with alteration of Adoptive Mother function and interaction between Neuroglia-neurons. Healthy interactions! Adult microglia (green) intertwined with hippocampal neurons (red )

12. The circle mind’s Conflictual Event-Brain’s Nervous Event should from by the Learning through a mechanism of implicit classic conditioning. Neural System of Implicit Memory should be take part in this pathway.

13. The System works during Slow Learning

14. The Vicious Circle Mind-Brain-Mind

15. Nitrogen Oxide and Pre-synaptic Stimulation Mind’s Conflictual Event-Brain’s Nervous Event

16. At last Global Alterated Signal will be Transmitted to the: • Under Cortical Centres • Medulla • Ganglions

17. Selfnourishment of the Stress Reaction with Block of the Action Chiefly act psychosocial stimulus

18. Chronic Activity of Biological System Stress Carriers • Neuroendocrine System (ACTH-cortisol-catecolamine- Pituitary Gland Hormones) • Antonomous Nervous System • Functional Alteration of Immunitary System • Neuropeptides • Noradrenergic • Serotoninergic • Dopaminergic • Gabaergic

19. Cause an upsetting of: • Psycho-Behavioral • Psycho-Biological reactions “Complex Response” Different from a subject to another, which is Psycho-Somatic disease to go so far as causing organic injury.

20. Alteration of the Mind-Brain Psycho- neurophysiologic transmission and communication could cause an alteration to Neuro-electric and Neuro-chemical level, intermediary among EGO and Behavior bring to a Psycho-somatic or Organic Disorder, disease or Cancer.

22. LEARNING AND PSYCHOMATOSIS

23. The conflictual event, and/or the life condition of Ego (stimulus), transmit in all her intensity to the mind where it causes the mental event. The conflictual event in the mind is not accepted, compared or, objectified by the mental reason, then it is not left in memory (experience), but it is anchored transitorily in the “subconscious mental one”

24. The energy bound to the conflictual event of burdens so on the mind in all its intensity and dramatic force and the conflict it becomes “INTRAPSYCHIC” and begins sending message to the cerebral cortex the mind event not material, in particular the intrapsychic conflict, itself unload at the same level, cortical, defining “The Nervous Cerebral Event”.

25. The cortical stimulation, causes the activation of working store in the neuron of the frontal cerebral lobes and the formation of “Memory Fields”. The memory’s field is an activated status in which electric signals are producer at speed more level than double compare to the base one (P.S. Goldman-Rakic et al. “Scientific American” 1992).

26. WORKING MEMORY Particular combination of awareness instant by instant and of immediate recovery of registered information. In fact the function of the WM is for its particular nature of short term activation, storage of symbolic information, and their manipulation and recovery of the informations stored in the long term memory, is to maintain the circuit S-R generated in this case by the conflictual event of the EGO (stimulus) that is the interaction Mind-Brain-Mind, that is (Mind-Subconscius) “Mind Conflictual Event” “Nervous Material Event” (Cerebral Cortex).

27. The circle that we have described itself would create by learning through a mechanism of “Classical Implicit Conditioning” where would intervene the neural system of the “Implicit Memory” that work during the long learning process.

28. The implicit memory is expressed by the activation of a particular sensory motor system and obtained and preserved from their intrinsic plasticity. The implicit memory together in the neural system of “Explicit Memory” registers information on the association of stimulus, but does not ask conscious participation of the subject again.

29. As reported by some authors (the learning for classical conditioning would be bound in a mechanism and associative post), that the associations they himself from with neural activity is coinciding in the pre-synaptic and post-synaptic neurons, with strengthening of the connection and it would be based on of a “Simple cellular mechanism” with pre-modulator character and located in the Hippocampus and it would suffer strengthening by convergence of the conditional or not stimulus inside the sensorial single neurons.

30. We know that associative pre-modulator mechanism pre- post-synaptic, contributes to the implicit classical conditioning, in which are associated two events: Not effective stimulus either conditional stimulus and one Hard effective stimulus, or not conditional stimulus.

31. At the beginning of the conditional stimulus (Bell-Ring) will not give an answer or only a small answer. If I couple a not conditional stimulus that is hard AS, E.G. running electric in the leg, the animal learn predictive connections among two stimuluses and it will raise to leg, where to feel the conditional stimulus in this conditioning are involved connections in neurons and target cells, interneuron and motor neurons.

32. We have so a convergence of conditional the same stimulus and of the not conditional one inside sensorial and single neurons, and stimulation produces exciter synaptic potential in the inter neurons and in the motor neurons, while not conditional strengthened stimuluses activated a lot of motor neurons groups.

33. Modulating serotoninergic neurons define a pre-synaptic facility of the sensorial neurons increasing serotonin release by pre-synaptic extremities and this facility contributed to not associated form of learning called Sensitization.

34. Hard effective stimulus that is not conditional correspond to the action of the modulating serotoninergic neurons, while the conditional stimulus activated the sensory neurons The animal learns strengthen reflected and varied answers of defensive type after having received a painful stimulus. This one is associated strengthening

35. The activated modulating neurons by the not conditional stimulus (kandel et al. 1992) free serotonin and define increase of the pre-synaptic facility of sensory neurons if these had as soon as starting action potential in answer to the conditional stimulus

36. This property called “facility dependent by the activity”, asks the same cellular synchronization demanded in the behavioral conditioning level and can explain this. Kandel et al. suggest that exist an cellular alphabet for the learning, where the mechanism of the most complex types than learning can be elaboration or combination at the simplest types or learning

37. On these bases Bucca suggests:

38. Main transmitter would be the Glutamate

39. Induction of long term strengthening, would happen on the NMDA receptor, that have associative proprieties, that is in identification of the coincidence (adenilciclasys)

40. Associated ionic channel to the receptor unblocks only when post-synaptic neuron is depolarized and the connection glutamate – receptor happens at the same time to the depolarization of the post-synaptic neuron “ Learning Synaptic Associative”

41. To this point the entrance of Calcium causes the LTS with starting of three different protein-kinases and the maintenance of the LTS, involves a pre-synaptic event with liberation of greater amount of transmitter at the pre-synaptic extremities The deregulation of the normal molecular pathway involved in signal transduction could be a cause of neoplastic cellular transformation

42. The LTS is a new form communication among the neurons “The II° Messengers Ways”, activated by the Ca2+ or perhaps the same activity of Ca2+, would cause release of a “Retrograde Plasticity Factor” by the active post-synaptic neuron.

43. This retrograde plasticity factor or retrograde messenger is “Nitrogen Oxide” (T.J. O’Dell et al. 1991) that acts on the pre-synaptic extremities only if in these, there is activity (Kandel et al. 1992) and it activates someone or more messenger that intensify the transmitters release and maintain the LTS

44. LTS uses a combination of two independent mechanism of associative synaptic learning: 1) Hebb’s Mechanism (D.O. Hebb) with NMDA receptor. 2) Not Hebb’s Mechanism of pre-synaptic facility Dependent by activity.

45. Max-Plank institutes Tobias Bonhoeffer studies, confirm the theory. The author asserts that LTS started in a post-synaptic neuron spread to the adjoning post-synaptic neurons and are interested only active pre-synaptic and specific nets Morris R et al. (Medical school of Edinburg) assert, LTS is involved in memory, process recording in the hippocampus. Which are mechanism that maintain-synaptic changes generated by explicit and implicit learning to Kandel et al. report that explicit and implicit memoring process proceed through stages. Short term memory lasts from few minutes to some hours and involves changes in the synaptic strength connections mediated by second messengers. Long term changes are recorded in the same site but ask genetic activation, expression of new genes and growing new connections. Bailey et al. Report that stimulouses that generate long term memory trough sensitization and classical conditioning lead in an increase of the number of the pre-synaptic terminations . Merzenik et al. assert, examining the sensorial cerebral cortex where is represented hand, shown that cortical maps change incessantly using sensorial nets. Bucca suggests: As the individual grows in different enviroments and exposed to different stimolouses and exercises his own personal sensomotory abilities with specific individual answers correlated to his genome and to personality structure, brain architecture so is different qualitatively and quantitatively among every individual. This characteristic modification of the brain architecture contributes to the biological basis of the expression of the individuality.