Muscle
Download
1 / 41

Muscle - PowerPoint PPT Presentation


  • 88 Views
  • Uploaded on

Muscle. Normal muscle. Muscle diseases. Primary Changes: Inflammation Structural (dystrophies and congenital myopathies) Metabolic diseases (eg glycogenoses, mitochondrial diseases) Secondary Changes: Neurogenic atrophy (due to loss of innervation and reiinervation). Neurogenic Atrophy.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Muscle' - nola-harrison


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript


Muscle diseases
Muscle diseases

  • Primary Changes:

    • Inflammation

    • Structural (dystrophies and congenital myopathies)

    • Metabolic diseases (eg glycogenoses, mitochondrial diseases)

  • Secondary Changes:

    • Neurogenic atrophy (due to loss of innervation and reiinervation)




Inflammatory myopathies1
Inflammatory myopathies

  • Dermatomyositis:

  • Polymyositis

  • Inclusion body myositis





Muscular dystrophies
Muscular Dystrophies

Characterized by:

  • Necrosis of individual muscle fibers

  • Accumulation of connective tissue around individual muscle fibers

  • Usually structural protein missing (genetic defect)



DMD

  • X-linked (males affected, female carriers)

  • Early onset (around 4 yoa)

  • Weakness Quadriceps and Gastrocnemius first followed by all proximal muscles

  • Often swollen gastrocnemius region early in disease.

  • If untreated (respiratory support), usual age of death around 18 yoa


ad