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Dynamic materials for controlling the cell microenvironment and drug release April M. Kloxin, Assistant Professor Chemical Engineering and Materials Science and Engineering College of Engineering. September 26 , 2011. Hydrogels for controlled cell culture.

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Dynamic materials for controlling the cell microenvironment and drug releaseApril M. Kloxin, Assistant ProfessorChemical Engineering and Materials Science and Engineering College of Engineering

September 26, 2011

hydrogels for controlled cell culture
Hydrogels for controlled cell culture

Molecular Details Macroscopic Structure

human mesenchymal stem cells

Live/Dead stain (Scale, 100 μm)

What are the important microenvironment signals for directing cell function in tissue regeneration or disease progression?

AM Kloxin, JA Benton, KS Anseth, Biomaters31 (2010) 1-8

AM Kloxin, MW Tibbitt, KS Anseth, Nature Protocols5 (2010) 1867-1887

AM Kloxin et al., Advanced Materials 22 (2010) 61-66

biomaterials approach to understanding and directing cell function
Biomaterials approach to understanding and directing cell function

Fundamental biological questions

Biomaterials development

Tissue regeneration

or disease treatment

Ligament

Fibrocartilage

  • MSC homing, function, and fate
  • Breast cancer cell dormancy/activation
  • Size- & time-scales for optimal drug release
  • Complex tissue regeneration
  • Model system and targets for disease regulation
  • In situ multiple-trigger drug delivery

Bone

Responsive

Materials

AM Kloxin, CJ Kloxin, CN Bowman, KS Anseth, Adv Materials22 (2010) 3484-3494

MW Tibbitt and KS Anseth, Biotech Bioeng103 (2009) 655-663

Image (right): ES Place, ND Evans, MM Stevens, Nature Materials 8 (2009) 457-470

responsive materials platform for dynamic cell culture
Responsive materials platform for dynamic cell culture
  • Property control on multiple
    • size scales: nano-, micro-, and meso-scale
    • time scales: seconds/minutes, hours, and days
  • Appropriate physical structure and chemical functionalities

Biomimetic tethers include peptide ECM mimics, cytokines, and growth factors

Similar platform can be used for controlled drug release with multiple triggers

AM Kloxin, AM Kasko, CN Salinas, KS Anseth, Science 324 (2009) 59-63

BD Fairbanks, …, KS Anseth, Adv Mater 21 (2009) 5005-5010

our facilities team
Our Facilities & Team

Offices

207 Colburn

129 Colburn (students)

Materials & Assays

220 & 221 Colburn

Cell Culture

126 Colburn (Colby Lab)

Collaborators

Kenneth van Golen (UD)

Kristi Kiick (UD)

David Colby (UD)

Raja Sivamani (UC-Davis)

The Group

Eric Macedo

Matthew Rehmann

Dynamic Materials &

Regenerative Medicine

AprilKloxinGroup.org

Funding

Pilot Project, NIH COBRE P20-RR016458

Pilot Project, NIH COBRE P20-RR017716