NSF-NSEC for Integrated Nanopatterning and Detection Technologies

1. 2 nm MOSFET-embedded microcantilevers Protein biomarker identification Improved bio-barcode assay Integrated chip-based detection system Surface immobilized bio-barcode assay MOSFET-MC design and development MOSFET-MC with integrated microfluidics NSF-NSEC for Integrated Nanopatterning and Detection Technologies (NSEC Grant Number EEC – 0647560 ) Chad A. Mirkin (PI), Michael Bedzyk, VinayakDravid, Horacio Espinosa, Franz Geiger, Mark Hersam, Joseph Hupp, Sonbinh Nguyen, Monica Olvera de la Cruz, George Schatz, Richard Van Duyne, William Klein, Chang Liu, Milan Mrksich, Steve Sligar, Teri Odom, Steve Wolinsky, Laurie Zoloth, MercouriKanatzidis, Jiaxing Huang, C. Shad Thaxton Northwestern University, University of Chicago, University of Illinois, Urbana-Champaign Ac-GXKAcZGC-NH2 Detector X Position D N E Q K R H S T M W F Y V I L A G P Alkanethiolate D N E MS Q Alkyldisulfide K R Z Position H S T M m/z W F Y V I L A G P Education/Outreach SRG 1: Nanopatterning 0 1 Research Experience for Undergraduates Research Experience for Teachers Partnership with the Museum of Science and Industry, Chicago • Resulting in 2,400 square ft permanent exhibit on nanotechnology • Opening 2010 • Potential to reach over 2 million visitors per year • DiscoverNano Website(www.discovernano.northwestern.edu) • >900,000 visitors a year • Includes: • Introduction to nanotechnology • Historical timeline • Nano Art Gallery • Curriculum projects • Meet the Researchers Nanotechnology Town Hall Meetings • Introduces nanotechnology to the public • Addresses societal/ethical concerns • 5 Town Halls to date, ~500 attendees • Nanoscience Pre-college Module • Inquiry-based, links to real-world applications, extensively field-tested • Includes student & teacher manuals • Being disseminated world-wide by NCLT • 164 REU Participants to date • 50% of participants women and underrepresented minorities • Hands-on research plus professional development activities • Technical writing course • Public Speaking workshop • Tour of Argonne National Laboratory • Final symposium and written paper • 90 published papers • Program includes hands-on research and curriculum development for their classrooms • 73 pre-college teachers have participated to-date • ~9000 pre-college students impacted to-date Dip-Pen Nanolithography Feedback Controlled Lithography Field Induced Oxidation 10 million Pen Array Intermolecular spacing with atomic precision Knowledge Transfer (to-date) • 630 publications • 183 provisional patents • 1,382 domestic and international seminars & colloquia • 93 Frontier in Nanotechnology Seminars • 6 International Institute for Nanotechnology Symposiums • 16 start-up companies launched through Small Business Evaluation & Entrepreneur’s (SBEE) Program (Over $400M invested) • 18 companies enlisted in Nanotechnology Corporate Partners (NCP) program • 65 Industrial partnerships • 42 International partnerships Nanoscape: The Journal of Undergraduate Research in Nanoscience • 80 Articles published to date • Undergraduate authors from institutions across the country • Volume VI I to be released Summer 2010 • On-line and print version • Print version mailed to >1,000 college and university departments and libraries 1.3 Million Probe 2-D 2-D Active Probe Arrays Parallel Inking Wells SRG 2: Signal Transduction & Receptor Design SRG 3:Integrated Biodetection Chip Flow 250 nm Aperture Lamp Spectrometer Flow cell New Receptor Chemistries Detection Strategies Enabled by NanoMaterials Profiling HDAC Activity Drug Binding to Membrane Proteins Measuring Telomerase Activity The authors wish to thank the National Science Foundation for their support of this work.