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Buchwald _ Hart wig Cross Coupling Reaction Wala Ghannam. *Objectives *Background *Reaction and Mechanism *Application and recent literature *Conclusion *References. Objective.

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Presentation Transcript
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*Objectives*Background*Reaction and Mechanism*Application and recent literature*Conclusion*References
objective
Objective

Base Effect and Inhibition of Catalytic Activity in Palladium-Catalyzed N-Heteroarylation of Pyrazoles with 2,6-Dibromopyridine

The Development of Versatile Methods for Palladium-Catalyzed Coupling Reactions of Aryl Electrophiles through the Use of P(t-Bu)3 and PCy3 as Ligands

Fluoride-Promoted Cross-Coupling Reactions of Alkenylsilanols. Elucidation of the Mechanism through Spectroscopic and Kinetic Analysis

Cross-Coupling Reactions of Aromatic and HeteroaromaticSilanolates with Aromatic and Heteroaromatic Halides

Biological Properties of Single Chemical?DNA Adducts: A Twenty Year Perspective

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BackgroundThe Buchwald-Hartwig reaction in its original scope is an organic reaction describing a coupling reaction between an arylhalide and an amine in presence of base and a palladiumcatalyst forming a new carbon-nitrogen bond.

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Recent LiteratureSynthesis of Bulky and Electron-Rich MOP-type Ligands and Their Applications in Palladium-Catalyzed C-N Bond Formation

(t-Bu)2PNP(i-BuNCH2CH2)3N: New Efficient Ligand for Palladium-Catalyzed C-N Couplings of Aryl and Heteroaryl Bromides and Chlorides and for Vinyl Bromides at Room Temperature

application
Application
  • An Efficient Process for Pd-Catalyzed C−N Cross-Coupling Reactions of Aryl Iodides: Insight Into Controlling Factors
  • Palladium-Catalyzed Coupling of Ammonia with Aryl Chlorides, Bromides, Iodides, and Sulfonates: A General Method for the Preparation of Primary Arylamines
  • Transition-Metal-Free O-, S-, and N-Arylation of Alcohols, Thiols, Amides, Amines, and Related Heterocycles
conclusion
Conclusion

Buch wald_Hartwig an important organic reaction uses for several thinges such as , A Highly Active Catalyst for Pd-Catalyzed Amination Reactions: Cross-Coupling Reactions Using Aryl Mesylates and the Highly Selective Monoarylation of Primary Amines Using Aryl Chlorides.

Thank you For listening

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References^ John P. Wolfe and Stephen L. Buchwald (2004), "Palladium-Catalyzed Amination Of Aryl Halides And Aryl Triflates", Org. Synth., http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=v78p0023 ; Coll. Vol. 10: 423 ^ N. B. Kondratenko, A. A. Kolomejcev, B. O. Mogilevskaya, N. M. Varlamova, L. M. Yagupolskii (1986). "Poly(nitro- and trifluoromethylsulphonyl)substituted diphenylamines". Zh. Org. Khim. (Rus.) 22 (8): 1721–1729. ^ Frederic Paul, Joe Patt, John F. Hartwig (1994). "Palladium-catalyzed formation of carbon-nitrogen bonds. Reaction intermediates and catalyst improvements in the hetero cross-coupling of aryl halides and tin amides". J. Am. Chem. Soc. 116: 5969–5970. doi:10.1021/ja00092a058.