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Advancements in Gene Expression and Morphometric Studies in Zebrafish and Mouse Models

This project brings together researchers from various institutions to explore gene expression and morphometric variations in zebrafish and mouse models. By developing comprehensive atlases utilizing MRI and optical imaging, the team aims to advance understanding in craniofacial genetics. With support from GWAS, the study identifies normal midface variations in humans and employs mutant models for research on cleft palate conditions. The involvement of the NIDCR and other academic institutions enhances collaborative efforts in this critical field of biomedical research.

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Advancements in Gene Expression and Morphometric Studies in Zebrafish and Mouse Models

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  1. Clouthier, Artinger, Postlethwait (U Colorado U Oregon) miRNAs (zebrafish mouse) Fraser (CalTech) Develop atlases (MRI, optical, in situ) (mouse & quail) Beaty (Hopkins) GWAS confirmation (human) Steering Committee (project PIs & NIDCR) FaceBase Organization Potter (U Cincinnati) Gene expression atlas (microarray) (mouse) Shapiro (U Washington) Shape-based image retrieval (human) NIDCR program Coordinating hub Murray/ Marazita (Iowa, Pittsburgh) Scientific Leadership Group Chai (USC) Mutant models/ microCT/MRI (mouse & chick) Marazita, Weinberg (U Pittsburgh) GWAS of normal midface variation (human) Animal models Human Visel (LBNL) Genomic screen for craniofacial enhancers (mouse) Spritz (U Colorado) Genome-wide QTL Morphometry (mouse & human) Donahue, S. Murray (Jackson Labs) New conditional clefting models (mouse) research technology

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