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Acute Liver Failure William Bernal, M.D., and Julia Wendon , M.B., Ch.B.

Acute Liver Failure William Bernal, M.D., and Julia Wendon , M.B., Ch.B. Kurdistan Board GEH Journal club. Introduction:.

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Acute Liver Failure William Bernal, M.D., and Julia Wendon , M.B., Ch.B.

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  1. Acute Liver Failure William Bernal, M.D., and Julia Wendon, M.B., Ch.B. Kurdistan Board GEH Journal club

  2. Introduction: iT Is a rare life-threatening critical illnessoccurs most often in patients who do not have preexisting liver disease. incidence <10 cases per million persons per year seen most commonly in 30s it presents unique challenges in clinical management.The clinical presentation usually includes hepatic dysfunction, abnormal liver biochemical values, coagulopathy; encephalopathy may develop, with multiorganfailure& death occurring in up to 50%The rarity ,severity& heterogeneity, has resulted in a very limited evidence base to guide supportive care. survival have improved substantially in recent years through advances in critical care management & emergency liver transplantation.

  3. Definition: “a severe liver injury, potentially reversible in nature with onset of hepatic encephalopathy within8 weeks of the first symptoms in the absence of pre-existing liver disease,”. In hyperacutecases, this interval is a week or less&the cause is usually acetaminophen toxicityor a viral infection. More slowly evolving, or subacute, cases:may be confused with chronic liver disease.often result from idiosyncratic drug-induced liverinjury or indeterminate cause. despite having less marked coagulopathy & encephalopathy, have a consistently worse outcomewith medical care alone.

  4. BO5s: The most common cause of viral-induced Acute Live Faliure is: Hepatitis A. Hepatitis B. Hepatitis C. Hepatitis E. A&D.

  5. BO5s: The most common cause of viral-induced Acute Live Faliure is: Hepatitis A. Hepatitis B. Hepatitis C. Hepatitis E. A&D.

  6. BO5s: Subacute compared with acute acute Live Failure is characterized by all except: Simulates chronic liver disease. Has better prognosis. Caused more by idiosyncratic drug reaction. Has less encephalopathy. Has less coagulopathy.

  7. BO5s: Subacute compared with hyperacuteacute Live Failure is characterized by all except: Simulates chronic liver disease. Has better prognosis. Caused more by idiosyncratic drug reaction. Has less encephalopathy. Has less coagulopathy.

  8. BO5s: Encephalopathy in acute liver failure differs from that in chronic liver disease by: Antibiotics has clear beneficial role. Lactulose has deleterious effects. Intra-cranial hypertension plays no important role. Hypothermia has no any benefits. Grading is different.

  9. BO5s: Encephalopathy in acute liver failure differs from that in chronic liver disease by: Antibiotics has clear beneficial role. Lactulose has deleterious effects. Intra-cranial hypertension plays no important role. Hypothermia has no any benefits. Grading is different.

  10. BO5s: Management of intra-cranial hypertension in acute liver failure include the following except: IV Manitol. Hypothermia. Indomethacin Thiopentone. IV hypotenic saline.

  11. BO5s: Management of intra-cranial hypertension in acute liver failure include the following except: IV Manitol. Hypothermia. Indomethacin Thiopentone. IV hypotenic saline.

  12. BO5s: The following contribute to intracranial hypertension in acute liver failure except: Hyperamonemia. Hyponatremia. Hypoglycemia. Infections. Renal failure.

  13. BO5s: The following contribute to intracranial hypertension in acute liver failure except: Hyperamonemia. Hyponatremia. Hypoglycemia. Infections. Renal failure.

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