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ON- und OFF-Switches. OFF-Switch: Bindung des Liganden schaltet die Genexpression ab - zuerst entdeckt (2002) (FMN- Riboswitch in B. subtilis ; thi -Riboswitch in E. coli ) Sensing small molecules by nascent RNA: a mechanism to control transcription in bacteria.

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on und off switches

ON- und OFF-Switches


Bindung des Ligandenschaltet die Genexpressionab

-zuerstentdeckt (2002)

(FMN-Riboswitch in B. subtilis; thi-Riboswitch in E. coli)

Sensing small molecules by nascent RNA: a mechanism to control transcription in bacteria.

Mironov AS, Gusarov I, Rafikov R, Lopez LE, Shatalin K, Kreneva RA, Perumov DA, Nudler E. Cell 2002 (5):747-56.

Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression.

Winkler W, Nahvi A, Breaker RR. Nature 2002 (419):952-6.


Bindung des LigandenschaltetGenexpression an


(Adenosin-Riboswitchkann ON- oder OFF-Switch sein)

Adenine riboswitches and gene activation by disruption of a transcription terminator.

Mandal M, Breaker RR. Nat Struct Mol Biol. 2004(11):29-35

lInzwischenkennt man für die meistenLigandensowohl

ON- alsauch OFF-Switches.

k lte sensitiver riboswitch oder rna thermometer
Kälte-sensitiverRiboswitch (oder RNA-Thermometer?)

Die mRNA für das ‘cold-shock’-Protein CspA in E. coli kann in Abhängigkeit von

derTemperatur 2 alternative Strukturenannehmen.

ErstesBeispielfür mRNA-Struktur, deren Expression beiKälterschockerhöhtist

  • Giuliodoriet al. Mol. Cell 2010