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Comparative Analysis of Previous and Current Models of CAR-T Cell Interactions with Tumor Cells

Explore the differences between previous human CAR-T cell models and current mouse CAR-T cell models in their interactions with human cancer cells and MHC-I Ag through TCR and CAR signaling pathways. Examine the roles of IFNγR in IFNγ regulation.

nichole-whitehead
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Comparative Analysis of Previous and Current Models of CAR-T Cell Interactions with Tumor Cells

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  1. A Previous models Human CAR+ T cells (allo/xenogeneic, polyclonal) Mouse stroma cells Human cancer cells MHC I TCR TCR MHC I Ag CAR CAR Ag IFNγR IFNγ IFNγR IFNγ B Currentmodel Mouse CAR+ T cells (non-specific, monoclonal) Mouse stroma cells Human cancer cells MHC I TCR TCR MHC I Ag CAR CAR Ag IFNγR IFNγ IFNγR IFNγ No interaction Interaction

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