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EBOLA. Comparative Virology October 2005. KARAN CHOPRA. MOHAN BOLISETTY. Virus Classification. Group : Group V (-)ssRNA . Order : Mononegavirales Family : Filoviridae Genus : Ebolavirus Ebola’s natural reservoir is unknown.

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EBOLA

Comparative Virology

October 2005

KARAN CHOPRA

MOHAN BOLISETTY

virus classification
Virus Classification

Group: Group V (-)ssRNA.

Order:Mononegavirales

Family:Filoviridae

Genus:Ebolavirus

  • Ebola’s natural reservoir is unknown.
  • Non human primates have been the source of human infections but are not thought to be the reservoirs.
history
History
  • Named after the Ebola River in the Democratic Republic of the Congo (formerly Zaire), near the first epidemics.
  • Two species were identified in 1976:
    • Zaire ebolavirus (ZEBOV) and
    • Sudan ebolavirus (SEBOV)
  • Case fatality rates of 83% and 54% respectively.
  • A third species, Reston ebolavirus (REBOV), was discovered in November 1989 in a group of monkeys (Macaca fascicularis) imported from the Philippines.
  • Ivory Coast ebolavirus – Only one case. Unlucky scientist.
saga continues
Saga Continues

http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/ebotabl.htm

most recent
Most Recent
  • April 25 – June 16 2005 total of 12 cases including 9 deaths were reported in Etoumbi and Mbomo in the Cuvette Quest Region.
modes of transmission
Modes of Transmission

There are 3 modes of infection:

  • Unsterilized needles
  • Suboptimal Hospital conditions
  • Personal contact

http://www.ecplanet.com/pic/2003/12/1071257871/ebola.jpg

symptoms
Symptoms
  • Onset of fever.
  • Intense weakness.
  • Muscle Pain.
  • Headache.
  • Soar Throat.
  • Vommitting, Diarrhoea.
  • Impaired Kidnay and liver function.
is there a cure
Is There a Cure?
  • There are no known curative medications for Ebola.
  • However, there have been very recent developments in preventative medications.
vaccines
Vaccines
  • In June, Jones and his colleagues, Dr. Heinz Feldmann of Winnipeg and Dr. Thomas Geisbert at Fort Detrick, Maryland announced that they had successfully vaccinated monkeys against the deadly Ebola virus
  • The Ebola vaccine is based on the 1976 strain of the Zaire species and protects from the 1995, but not the other 2 species that affect humans.
bioterrorism
Bioterrorism
  • Airborne transmission of Ebola Zaire has been demonstrated in monkeys in a controlled laboratory experiment
  • Plum Island…?
conclusion
Conclusion
  • Even though scientists have recently made breakthroughs there is still need for extensive research to find vaccines and cures for this deadly virus.
references
References
  • www.wikipidea.com
  • http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/ebotabl.htm
  • http://www.who.int/mediacentre/factsheets/fs103/en/
  • Hampton, Tracy. Vaccines Against Ebola and Marburg Viruses Show Promise in Primates Studies. Maedical News and Perspectives. JAMA. Vol. 294 No. 2 July 2005.
  • Jones, Steven. Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses. Nature Medicine. Vol. 11 No. 7 July 2005.