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Analysis of Anions in Toothpaste Using Ion Chromatography

This presentation explores the determination of fluoride and chloride levels in four toothpaste brands (Sensodyne, Colgate, Close-Up, and Hapee) through ion chromatography. The study reveals quantifiable chloride concentrations in only Sensodyne and Hapee, highlighting potential matrix effects in sample analysis. Recommendations for improved methodologies include using alternative mobile phases and engaging in thorough sample homogenization. This research contributes valuable insights into the chemical composition of consumer dental hygiene products.

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Analysis of Anions in Toothpaste Using Ion Chromatography

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  1. Instrumental Analysis, LaboratoryOral Presentation Nikko Bacalzo Douglas Dy Jeremy Ly France Tan

  2. Determination of Anions in Toothpaste by Ion Chromatography Instrument Used: Ion Chromatography

  3. FLUORIDE http://toxicfreekidsblog.org/2011/07/toxic-toothpaste/ http://www.webmd.com/oral-health/image-collection-oral-health#phototake_rm_photo_of_tooth_illustration.jpg

  4. http://www.skepticnorth.com/2010/10/fluoridiated-water-debate-returns-nothing-new-is-said/http://www.skepticnorth.com/2010/10/fluoridiated-water-debate-returns-nothing-new-is-said/ http://www.fluoridation.com/teeth.htm

  5. ION CHROMATOGRAPHY

  6. ION CHROMATOGRAPHY http://www.separations.us.tosohbioscience.com/ServiceSupport/TechSupport/ResourceCenter/PrinciplesofChromatography/IonExchange

  7. ION CHROMATOGRAPHY Injection valve Readout Filter Column Mobile phase/ solvent reservoir Detector Pump Excess/ waste

  8. Data and Results

  9. Data and Results Fluoride calibration curve

  10. Data and Results Chloride calibration curve

  11. Data and Results

  12. Data and Results

  13. Conclusion • Four toothpaste brands were analyzed for their fluoride and chloride contents (Sensodyne, Colgate, Close-Up and Hapee). • Standards were run in the ion chromatograph, and the retention times and the concentration-peak area relationships of each were drawn from the data. • Out of which only Sensodyne and Hapee showed quantifiable amounts of chloride in the toothpaste formulation. • Calculation yielded concentrations of 0.00923% and 0.016% chloride in both toothpastes, respectively. • Other samples had no sufficiently quantifiable amounts of both anions, suspected to be consequence of matrix effect.

  14. Recommendations • Use other MP: carbonate/bicarbonate buffer, KOH • Use gradient elution • Standard addition instead of calibration curve • Homogenization of samples • Analyze other anions (MFP, benzoate, sulfate, phosphate) • Method validation

  15. References • Takahara, Y, et al. Photooxidation of organic compounds in a solution containing hydrogen peroxide and TiO2particles under visible light. Journal of Applied Chemistry. Vol.35, 793-797.<http://www.springerlink.com/content/t866330021785302/> • Shimadzu Corporation. The UV-2401PC: A Superbly Engineered Instrument.Accessed on May 21, 2012. <http://www.pa.ibf.cnr.it/web/pdf/12.pdf>

  16. Thank you for listening

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