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SEX-LINKED INHERITANCE. Objectives. Meet with Thomas Hunt Morgan Define Sex Linkage Define Sex linkage in Drasophila melaganester Describe Hemoplia , colourblidness and Muscular dystrophies. SO WHAT IS SEX LINKED INHERITANCE ??. Thomas Hunt Morgan.

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objectives
Objectives
  • Meetwith Thomas Hunt Morgan
  • Define SexLinkage
  • Define Sexlinkage in Drasophilamelaganester
  • DescribeHemoplia, colourblidnessandMuscular dystrophies
thomas hunt morgan
Thomas Hunt Morgan
  • He was an American evolutionary biologist , geneticist and embryologist
  • Drosophila became a major model organism with his studies
  • Morgan hypothesized that an allele for eye color is carried on the X chromosome
  • Sex linkage was discovered by Thomas Hunt Morgan
slide6

Q1-In a cross between a white-eyed female fruit fly and red-eyed male, what percent of the female offspring will have white eyes? (White eyes are X-linked, recessive)

  • A. 100%B. 25%
  • C. 50%
  • D. 75%
  • E. 0%
slide7

Sex linkage is a term that applied to genes located on sex chromosomes.

  • A trait that is controlled by a gene found on the sex chromosome is a sex- linked trait.
slide8

Sex-Linked Inheritance In humans

X-linkedinheritance

Y-linkedinheritance

X-linkedrecessive

Xlinked dominant

x linked recessive inheritance
X-linkedrecessiveinheritance
  • X-linked inheritance means that the gene causing the trait or the disorder is located on the X chromosome
  • Recessive inheritance is when both matching genes must be abnormal to cause disease.
  • If only one gene in the pair is abnormal, the disease does not occur.
x linked recessive inheritance hemophlia
X-linkedrecessiveinheritanceHemophlia

Hemophilia is a rare bleeding disorder in which the blood doesn't clot normally.

If you have hemophilia, you may bleed for a longer time than others after an injury.

x linked recessive inheritance color blindness
X-linkedrecessiveinheritanceColor-Blindness
  • Color-blindness is the inability to distinguish the differences between certain colors..

The picture on the rightis how people with blue yellow color blindness see things.

slide13

Question 2: A human female "carrier" who is heterozygous for

the recessive, sex-linked trait causing red-green color blindness

(or alternatively, hemophilia), marries a normal male. What

proportion of their male progeny will have red-green color

blindness (or alternatively, will be hemophiliac)?

A. 100%

B. 75%

C. 50%

D. 25%

E. 0%

slide14

Q3:A human female "carrier" who is heterozygous for the recessive, sex-linked trait red color blindness, marries a normal male.

What proportion of their female progeny will show the trait?

A. All

B. 1/2

C. 1/4

D. 0

E. 3/4

x linked recessive inheritance muscular dystrophies
X-linkedrecessiveinheritanceMuscular dystrophies

Muscular dystrophy (MD) is a genetic disorderthat gradually weakens the body's muscles.

slide16

Additionally, numerous genes whose expression yields enzymes are sex-linked. Glucose-6-phosphate dehydrogenase and hypoxanthine-guanine-phosphoribosyltransferase are two examples.

In the latter case, the Lesch-Nyhan syndrome results from the mutant form of the X-linked gene product.

x linked dominant i nheritance
X-linked dominantinheritance
  • Disorders generally seen in females
  • Lethal in males
  • X-linked dominant disorders are less common than X-linked recessive disorders
y l inked inheritiance
Y-linkedinheritiance

1. excessively hairy

2-Ichthyosishystrix

resources
Resources
  • http://pennstatehershey.adam.com/content.aspx?productId=117&pid=2&gid=9882
  • http://www.britannica.com/EBchecked/topic/537011/sex-linked-character
  • http://ocw.tufts.edu/Content/20/lecturenotes/301642/301646
  • http://www.thereforyou.com/understanding-hemophilia/hemophilia-genetics/
  • http://www.nhlbi.nih.gov/health/health-topics/topics/hemophilia/
  • http://www.color-blind.org/Blue-Yellow-Color-Blindness.php
  • http://www.biology.arizona.edu/mendelian_genetics/problem_sets/sex_linked_inheritance/07Q.html
  • Ted Ankara CollagesTeacher’sNotes in Biotedwebsite