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The effect of food on triggering type II diabetes: modeling a CBD Pancreas

School of Computer Science. The effect of food on triggering type II diabetes: modeling a CBD Pancreas. Mohamed Raef Smaoui April 26 th , 2012. Outline. Role of pancreas Type II diabetes Modeling pancreas reaction (ODE) Modeling Beta Cells in pancreas (CBD) Simulation & Results. Outline.

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The effect of food on triggering type II diabetes: modeling a CBD Pancreas

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  1. School of Computer Science The effect of food on triggering type II diabetes: modeling a CBD Pancreas Mohamed RaefSmaoui April 26th, 2012

  2. Outline • Role of pancreas • Type II diabetes • Modeling pancreas reaction (ODE) • Modeling Beta Cells in pancreas (CBD) • Simulation & Results

  3. Outline • Role of pancreas • Type II diabetes • Modeling pancreas reaction (ODE) • Modeling Beta Cells in pancreas (CBD) • Simulation & Results

  4. What happens when you eat?

  5. Role of pancreas

  6. Role of pancreas

  7. Outline • Role of pancreas • Type II diabetes • Modeling pancreas reaction (ODE) • Modeling Beta Cells in pancreas (CBD) • Simulation & Results

  8. Type II diabetes

  9. Type II diabetes (beta cells)

  10. Type II diabetes (amyloids)

  11. Glucose / Insulin in Diabetes Pancreas GLUCOSE INSULIN Beta-Cells

  12. Outline • Role of pancreas • Type II diabetes • Modeling pancreas reaction (ODE) • Modeling Beta Cells in pancreas (CBD) • Simulation & Results

  13. Pancreas reaction ODE Victor Bolie, Coefficients of normal blood glucose regulation, J of Applied Physiology 61

  14. Glucose / Insulin in Diabetes GLUCOSE INSULIN

  15. Glucose / Insulin in Diabetes Pancreas GLUCOSE INSULIN Beta-Cells

  16. Outline • Role of pancreas • Type II diabetes • Modeling pancreas reaction (ODE) • Modeling Beta Cells in pancreas (CBD) • Simulation & Results

  17. Simulation (demo) • buildSystem.py

  18. 1700 Cal /day (400 breakfast, 900 lunch, 400 dinner)

  19. 2500 Cal /day (200 breakfast, 1300 lunch, 1000 dinner)

  20. 4000 Cal /day (650 breakfast, 3000 lunch, 350 dinner)

  21. Conclusion • Modelled Glucose / Insulin (ODE) • 100 Beta cells cooperate to produce insulin • Each Beta Cell can • produce variable insulin and amylin (Dirichlet dist) • Infect neighbors upon death • Diet recommendation by myHealth.py

  22. References • Westermarket al., Islet amyloid polypeptide, islet amyloid, and diabetes mellitus, Physiol Rev (2009). • Marzbanet al., Islet amyloid polypeptide and type 2 diabetes, Experimental Gerontology (2003). • Lara and Vangheluwe, Atom3: a tool for multi-formalism meta-modeling, ETAPS (2002). • Smaoui, A computational framework to create an ensemble of stable amyloid fibrils, McGill University (2011). • Victor Bolie, Coefficients of normal blood glucose regulation, J of Applied Physiology (1961).

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