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Genetic Analysis of hcnABC Loci in B. cenocepacia Chromosomes

This study examines the hcnABC loci in B. cenocepacia chromosomes 2 and 3, revealing variations in the gene sequences and their expression levels. Through detailed analysis, the roles of hcnA, hcnB, and hcnC in the pathogenicity of B. cenocepacia are elucidated.

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Genetic Analysis of hcnABC Loci in B. cenocepacia Chromosomes

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  1. A B. cenocepacia chromosome 2 BCAM1268-9 P. aeruginosahcnABC locus C “B” BCAM1269 B “C” “A” BCAM1268 A BCAM1268a “A” “A” hcnC (30%) hcnA (45%) hcnB (32%) “B” “B” B. cenocepacia chromosome 2 BCAM0667-9 B. Cenocepacia chromosome 3 BCAS0163-5 BCAS0165 BCAM0668 BCAS0163 BCAS0164 “C” “C” BCAM0669 BCAM0667 hcnC (29%) hcnB (34%) hcnA (37%) hcnB (33%) hcnA (39%) hcnC (28%) B 104105 97 97 99 PAO1 HcnA ...... PF– 5 HcnA ...... BCAM1268a ...... BCAM0669 ...... BCAM0164 ...... C ...... 464 ...... 469 ...... 417 ...... 480 ...... 478 PAO1 HcnB PF– 5 HcnB BCAM1269 BCAM0668 BCAM0163 D PAO1 HcnC PF– 5 HcnC BCAM1268 BCAM0667 BCAM0165 ......413 ...... 413 ...... 355 ...... 374 ...... 371

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