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Women’s Health And The Women’s Health Initiative Study. Lisa Killinger, DC. The Women's Health Initiative (WHI) is a major 15-year research program to address the most common causes of death, disability and poor quality of life in postmenopausal women --. Primary topics studied:.

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Women’s Health And The Women’s Health Initiative Study


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The Women's Health Initiative (WHI) is a major 15-year research program to address the most common causes of death, disability and poor quality of life in postmenopausal women --

primary topics studied
Primary topics studied:
  • cardiovascular disease
  • cancer
  • osteoporosis
more on the whi
More on the WHI
  • Launched in 1991
  • A set of clinical trials
  • One observational study
  • Involve more than 161,000 women
  • Mostly healthy & postmenopausal
randomized clinical trial rct
Randomized Clinical Trial (RCT)
  • Hormone Replacement Therapy Trial (HRT)
  • Dietary Modification Trial (DM)
  • Calcium/Vitamin D Supplementation Trial (CaD)
observational study os
Observational Study (OS)
  • OS Participants:
    • From 40 Clinical Centers (CC) nationwide
    • 167,000 women aged 50-79; 67,000 in RCT 100,000 in OS
    • 20% overall minority recruitment:10 CC's with goal of 60%
community prevention study cps
Community Prevention Study (CPS)
  • CPS Participants:
    • at CDC funded University-based Prevention Research Centers
cps study topics
CPS Study Topics
  • Reducing CVD Risk Among Black Women (Johns Hopkins)
  • CVD Peer Support in Afr-American Women (U Alabama)
  • Environmental Factors & Physical Activity in Women (SLU)
  • Osteoporosis Prevention (UNC; Chapel Hill)
  • Diabetes Care in Minority Women (UNC)
whi hrt study the pill and its effect on women
WHI- HRT studyThe “pill” and its effect on women
  • Heart Disease
  • Breast Cancer
  • Osteoporosis
  • Stroke
  • Dementia
estrogen progestin vs placebo
Estrogen + Progestin vs. Placebo

The rate per 10,000 women per year

summary of results heart
Summary of Results: Heart
  • Women on Estrogen/Progest Pill not protected from heart disease
  • E & P: 24% Increase in heart disease risk
  • Highest risk increase in women w/ hi LDL

Manson, et al. NEJM Aug 7, 2003. Vol. 349(6):523-534.

summary of results breast cancer
Summary of Results: Breast Cancer
  • E & P Group: 24% increase in Breast Cancer risk

Chebowski, et al. JAMA 2002 June 225. Vol. 289(24): 3243-3254.

results dementia
Results: Dementia
  • May, 20, 2003 JAMA
  • E&P Group: Twice the risk of dementia (Alzheimer’s)
  • Resource Orgs:
    • www.alzheimers.org
    • ADEAR: 1-800-438-4380
other results
Other Results…
  • E&P and Stroke: Risk increased 31%
  • E &P and Blood Clots: Risk increased 61%
  • Osteoporosis and Colorectal Cancer: E&P may protect, but risks outweigh the benefits
  • E&P part of study was cancelled due to increased rates of disease!
resources on women s health
Resources on Women’s Health
  • www.4women.org
  • Nat’l Women’s Health Info Center
  • 1-800-994-Woman
  • www.nhlbi.nih.gov/whi (women’s health init)
  • National Domestic Abuse Hotline: 1-800-799-SAFE (violence is a leading cause of injury in women ages 15-54)