Combinatorial chemistry. The basic principles. What is it about?. Synthesising a large number of similar compounds in a short period of time. Compounds that are generated are analogues of compounds that are already biologically active
The basic principles
2. React the beads with a group called a linker
3. Mix the bead in with an alcohol that you want to use in a chemical reaction. The linker will bind to it and hold it on the bead.
6. The beads are removed from the vessel by lifting up the mesh bag. They are washed to remove any unreacted acyl chloride
7. A reaction is used to break the linker group down.
8. The polymer beads are reused
9. You have made 6 different esters which can now be tested for biological activity
10. How many esters would you have made if you had attached 6 different alcohols to the beads?
Large numbers of similar compounds have
been synthesised in a very short period
of time. Imagine how much longer it would
take if you did the reaction with one alcohol
and acyl chloride, and then did it again with a
different acyl chloride, and then again,
and again…. 36 times!