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Review of HLA Tables (2016)

Review of HLA Tables (2016). Histocompatibility Committee. What problem will the proposal solve?. Members need updated antigens in UNet SM As a result of the naming process for DPB1 alleles, there is no relationship between the allele designation and the protein structure.

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Review of HLA Tables (2016)

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  1. Review of HLA Tables (2016) Histocompatibility Committee

  2. What problem will the proposal solve? • Members need updated antigens in UNetSM • As a result of the naming process for DPB1 alleles, there is no relationship between the allele designation and the protein structure. • Only a small number of DPB1 antigens are present on commercial antibody testing kits. • Hence, the possibility exists that an incompatible organ may be inappropriately offered to a candidate. The downstream impact ranges from an unexpected positive crossmatch to early AMR and graft loss. • Nomenclature in tables is out of date

  3. What are the proposed solutions? • Update existing equivalency tables • Add HLA-DPB1 unacceptable antigen table, including G alleles • Update nomenclature in all equivalency tables to reflect proper WHO designations. • HLA-A 101  HLA- A*01:01

  4. How will members implement this proposal? • Members should: • familiarize themselves with updates to tables • review and modify unacceptable antigens for candidates based on changes to tables • Members must update their references and reporting methods to reflect changes in nomenclature

  5. How will the OPTN implement this proposal? • Anticipated Board of Directors Review: Dec. 2017 • Programming – IT will update tables in Policy 4.10 with changes to nomenclature and antigens • Committee will evaluate 1 year post-implementation

  6. Questions? Robert A. Bray, Ph.D., D(ABHI), HCLD/CC(ABB) Committee Chair rbray@emory.edu Alison Wilhelm Committee Liaison alison.wilhelm@unos.org

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