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Comparison of In vitro efficacy of linezolid and vancomycin against methicillin resistant Staphylococcus aureus (MRSA). Dr Fatima Kaleem. Introduction.
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Dr Fatima Kaleem
Assadullah, S et al., 2003, Sonavane, A, 2007, Mehdinejad, M et al., 2008, Horieh, S et al., 2005.
Vancomycin has a narrow spectrum of activity, restricted mostly against Gram-positive bacteria, and is potentially the drug of choice for the treatment of methicillin resistant Staphyloccus aureus.
Methicillin resistant Staphylococcus aureus ATCC 33591 and methicillin sensitive Staphylococcus aureus (MSSA) ATCC 25923 were used as control strains.
Fig 1: Graph showing comparison of MIC 50 and MIC 90 of vancomycin and linezolid.
X axis shows drugs and Y axis shows MIC in ug/ml.
Most of the MRSA isolates were isolated from pus samples followed by nasobronchial lavage and urine.
Linezolid'soral dosing option may allow earlier discharge of hospitalized patients thus reducing bed occupancy, over head charges and is a cost effective option from patient’s point of view.
It is recommended so as to prevent the emergence of Vancomycin resistant Strains of MRSA.
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Antibiotics will never be an effective alternative to good medical practice