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Dynamic Control of Molecular Motor Traffic in Biological Cellular Networks

Explore the impact of intracellular transport breakdown on diseases through studying molecular motor network dynamics. Investigate traffic jams formation at network intersections. Utilize numerical model for topology analysis and comparison with experiments. Contact for Bachelor project: Daniël Miedema, d.m.miedema@uva.nl, Dmitry Denisov, d.denisov@uva.nl, Peter Schall, ps@peterschall.de. Collaboration with AMOLF and ITFA.

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Dynamic Control of Molecular Motor Traffic in Biological Cellular Networks

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  1. Traffic jam in biological cellular networks Efficient transport of cargo is of vital importance in biological cells and to all living organisms. The break down of intracellular transport is associated with various diseases. We study dynamic arrest of molecular motors moving along networks in biological cells both expermimentally and numerically. At intersections in the network motors start to aggreagate, forming biological traffic jams. Molecular motors • In this Bachelor project we take the network point of view on intracellular transport problems. • Using a simple numerical model we aim to study the importance of the network topology. • Direct comparison with experiments can be made. Experiments showing the network (blue) and traffic jams (red) (Experience with Matlab or C++ is a plus ) • Contact : Daniël Miedema, d.m.miedema@uva.nl, Dmitry Denisov, d.denisov@uva.nl • Peter Schall, ps@peterschall.de In collaboration with AMOLF and ITFA.

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