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  1. Be a Champion 2005 Workshop

  2. Richard Higbee Vice President Global Marketing

  3. Our Promise • We promise you will leave with . . . • A Clear Understanding of the Pharmanex Vision and Strategy • A Conviction That Pharmanex Products Change Lives • Key Message Points That Will Help You Build Your Business “Business Take-aways”

  4. The Pharmanex Strategy Our strategy is to leverage science in order to create the most innovative sponsoring products in the dietary supplement and functional foods industry.

  5. Michael Chang, Ph.D. Joseph Chang, Ph.D. Chief Scientific Advisor, Pharmanex Fellow President of Pharmanex

  6. First Pharmanex office

  7. Homestead

  8. A Victory for CholestinTM and 57 Million Americans Cholestin, Good News for Better Health. Here’s some very good news for the estimated 57 million Americans who want a safe and 100% natural way to promote and maintain healthy cholesterol levels* – Cholestin is not a drug. A recent federal court ruling said that Cholestin meets all criteria as a dietary supplement. This distinction means that you can continue to enjoy direct access to this remarkably effective product, giving you an extremely strong weapon in the fight for better health. Research Confirms Cholestin Works. Cholestin’s benefits have been supported by over 30 clinical studies, all of which produced impressive results. Most recently, a double-blind, placebo-controlled study of Cholestin’s patented form of red yeast rice, was conducted by the UCLA School of Medicine and published by the American Journal of Clinical Nutrition. The studies measured the effects on cholesterol levels before and after supplementation with Cholestin. It was proven that Cholestin was effective compared to the placebo group.

  9. USA Today Circa 1997

  10. Pharmanex®= “Pharma-Next” “Next Generation Pharmaceutical”

  11. I See a Future…

  12. I See a Future… • You as ambassadors of good health

  13. I See a Future… • You as ambassadors of good health • The world knowing their antioxidant score

  14. Extraordinary Science… Personalized Revolutionized Simplified

  15. Extraordinary Science… Personalized Revolutionized Simplified

  16. Antioxidant Score 35,000 30,000 29,236 25,000 25,612 20,000 20,835 15,000 16,603 10,000 < 25 25-29 30-39 > 40 Body Mass Index Body Fat and Antioxidant Protection

  17. Breaking News: Landmark Scanner Study Skin Carotenoid Score = Antioxidant Protection

  18. Extraordinary Science… Personalized Revolutionized Simplified

  19. Lighter –Smaller –Faster

  20. Global Rollout • China, Europe, US Markets • February 2006 • Other markets soon after! • Learn more in your regional meeting

  21. I See a Future… • A Winning Strategy

  22. I See a Future… • A Winning Strategy • Simplicity

  23. Extraordinary Science… Personalized Revolutionized Simplified

  24. Now is the time to Scan the World! 10 Million People by 2007

  25. Michael’s Business Take-aways • Original Pharmanex Slogan: “Pharmaceutical companies improve health with medicines, Pharmanex improves health without medicine” • Pharmanex is derived from “Pharma-next” or “Next Generation Pharmaceutical”

  26. Joe’s Business Take-aways • 10M by 2007 • The scanner is the gold standard for overall antioxidant protection • We must “SCAN THE WORLD”

  27. Major Accomplishments • Global Product Rollout • BioPhotonic Scanner • TRA • Marine Omega • Estera • Stevie Award; NBJ Award • Product Certifications • China Manufacturing • Scanner “Oxidative Stress” Study

  28. Science & Tradition Mark R. Bartlett Ph.D. Sr. Director Pharmanex New Product Development

  29. Fruit Phytonutrients • At least 1,000 phytochemicals identified with cell protective effects • Very few (25) studied • Fruits and vegetables – more than meets the eye • We don’t eat enough fruits and vegetables

  30. 3 years ago…Pharmanex began Searching the World for Superfruits • R&D evaluated hundreds of fruits for… • Extraordinary antioxidant power (Scanner) • Extraordinary nutritional contents • Quality of scientific efficacy data • Impeccable safety data • History of traditional folklore usage

  31. Why the long search and Why the long list?

  32. Free Radicals Sources • Environmental pollution (smog, ozone, NO2) • Radiation exposure: • sunlight (UV-light), X-rays, etc. • Smoking: • 10,000,000,000,000,000 free radicals/cigarette! • Eating and Breathing: metabolism in your mitochondria

  33. SOD CAT Mitochondria – The Energy Furnaces of the body Free Radicals

  34. Pharmanex Research Centerswere involved… • Provo R&D Center • Shanghai R&D Center • Beijing R&D Center

  35. years of searching • Almost all failed Selection criteria • All but Four (g+3) very special fruits

  36. Gâc -“Fruit From Heaven” • Indigenous to Southern Asia Bangladesh, Burma, Cambodia, China, India, Japan, Laos, Malaysia, Philippines, Thailand, and Vietnam • Traditionally used internally and externally Topical: wound healing Internally: eye health, and to promote growth in children

  37. Extraordinarily rich in antioxidants, esp. lycopene, beta-carotene, vitamin E • Unique fatty acids → Lipocarotenes™ Antioxidants in Gâc Pulp Pulp (aril) Fruit flesh (mesocarp) Seeds

  38. Pharmanex Research Centers 3 Years of Searching and R&D • Gâc fruit (Chinese Bitter Cucumber) • Chinese Lycium (Wolfberry) • Cili fruit • Siberian Pineapple (Seabuckthorn) 3 +1 Superfruits

  39. 70 x more than tomatoes! Gac Fruit Lycopene Content mcg/g wet weight Ishida et al., J Agric Food Chem 52:274, 2004

  40. 10 x more than carrots! Gac Fruit Beta-CaroteneContent mcg/g wet weight Ishida et al., J Agric Food Chem 52:274, 2004

  41. Gâc Fights Vitamin A Deficiency • …a Leading cause of blindness in the world • In So. Asia, Gâc discovered as potent indigenous source of highly bioactive provitamin A (b-carotene) • 10 years of research by Dr. Le Vuong, Univ. of California, Davis, Nutrition Department *Vuong LT et al., Am J Clin Nutr 2002;75:872-879.

  42. Zeaxanthin in Chinese Lycium Fruit 40 x more than yellow corn! mcg/g wet weight

  43. Vitamin C in Cili Fruit 60 x more than oranges! mg/100g wet weight

  44. Lipocarotenes™ • Nature’s unique nutrient delivery system in • Gâc • contain fatty acids (unique among fruits) • with carotenoids & vitamin E pre-dissolved • Gâc carotenes: 40 % improved uptake* *compared to beta-carotene powder. Vuong LT et al., Am J Clin Nutr 2002;75:872-879.

  45. Betacarotene Lutein Vitamin C Lycopene Vitamin E Vulnerable to Oxidation

  46. SOD Catalase Vitamin E SOD CAT Internal Antioxidants