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Be a Champion 2005 Workshop. Richard Higbee Vice President Global Marketing. Our Promise . We promise you will leave with . . . A Clear Understanding of the Pharmanex Vision and Strategy A Conviction That Pharmanex Products Change Lives

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be a champion 2005 workshop
Be a Champion

2005 Workshop

our promise
Our Promise
  • We promise you will leave with . . .
  • A Clear Understanding of the Pharmanex Vision and Strategy
  • A Conviction That Pharmanex Products Change Lives
  • Key Message Points That Will Help You Build Your Business

“Business Take-aways”

the pharmanex strategy
The Pharmanex Strategy

Our strategy is to leverage science in order to create the most innovative sponsoring products in the dietary supplement and functional foods industry.

michael chang ph d
Michael Chang, Ph.D.

Joseph Chang, Ph.D.

Chief Scientific Advisor, Pharmanex Fellow

President of Pharmanex

slide8

A Victory for CholestinTM and

57 Million Americans

Cholestin, Good News for Better Health.

Here’s some very good news for the estimated 57 million

Americans who want a safe and 100% natural way to

promote and maintain healthy cholesterol levels* –

Cholestin is not a drug. A recent federal court ruling said

that Cholestin meets all criteria as a dietary supplement.

This distinction means that you can continue to enjoy

direct access to this remarkably effective product, giving

you an extremely strong weapon in the fight for better

health.

Research Confirms Cholestin Works.

Cholestin’s benefits have been supported by over 30 clinical studies, all of which produced impressive results.

Most recently, a double-blind, placebo-controlled study

of Cholestin’s patented form of red yeast rice, was

conducted by the UCLA School of Medicine and

published by the American Journal of Clinical Nutrition.

The studies measured the effects on cholesterol levels before and after supplementation with Cholestin. It was proven that Cholestin was effective compared to the placebo group.

slide9

USA Today

Circa 1997

pharmanex pharma next

Pharmanex®= “Pharma-Next”

“Next Generation Pharmaceutical”

i see a future14
I See a Future…
  • You as ambassadors of good health
i see a future15
I See a Future…
  • You as ambassadors of good health
  • The world knowing their antioxidant score
extraordinary science
Extraordinary Science…

Personalized

Revolutionized

Simplified

extraordinary science17
Extraordinary Science…

Personalized

Revolutionized

Simplified

body fat and antioxidant protection

Antioxidant Score

35,000

30,000

29,236

25,000

25,612

20,000

20,835

15,000

16,603

10,000

< 25

25-29

30-39

> 40

Body Mass Index

Body Fat and Antioxidant Protection
slide19
Breaking News:

Landmark Scanner Study

Skin Carotenoid Score = Antioxidant Protection

extraordinary science20
Extraordinary Science…

Personalized

Revolutionized

Simplified

global rollout
Global Rollout
  • China, Europe, US Markets
    • February 2006
  • Other markets soon after!
  • Learn more in your regional meeting
i see a future24
I See a Future…
  • A Winning Strategy
i see a future25
I See a Future…
  • A Winning Strategy
  • Simplicity
extraordinary science26
Extraordinary Science…

Personalized

Revolutionized

Simplified

now is the time to scan the world
Now is the time to Scan the World!

10 Million People

by 2007

michael s business take aways
Michael’s Business Take-aways
  • Original Pharmanex Slogan:

“Pharmaceutical companies improve health with medicines, Pharmanex improves health without medicine”

  • Pharmanex is derived from “Pharma-next” or “Next Generation Pharmaceutical”
joe s business take aways
Joe’s Business Take-aways
  • 10M by 2007
  • The scanner is the gold standard for overall antioxidant protection
  • We must “SCAN THE WORLD”
major accomplishments
Major Accomplishments
  • Global Product Rollout
    • BioPhotonic Scanner
    • TRA
    • Marine Omega
    • Estera
  • Stevie Award; NBJ Award
  • Product Certifications
  • China Manufacturing
  • Scanner “Oxidative Stress” Study
science tradition
Science & Tradition

Mark R. Bartlett Ph.D.

Sr. Director Pharmanex New Product Development

fruit phytonutrients
Fruit Phytonutrients
  • At least 1,000 phytochemicals identified with cell protective effects
  • Very few (25) studied
  • Fruits and vegetables – more than meets the eye
  • We don’t eat enough fruits and vegetables
3 years ago pharmanex began searching the world for superfruits
3 years ago…Pharmanex began Searching the World for Superfruits
  • R&D evaluated hundreds of fruits for…
    • Extraordinary antioxidant power (Scanner)
    • Extraordinary nutritional contents
    • Quality of scientific efficacy data
    • Impeccable safety data
    • History of traditional folklore usage
free radicals sources
Free Radicals Sources
  • Environmental pollution (smog, ozone, NO2)
  • Radiation exposure:
    • sunlight (UV-light), X-rays, etc.
  • Smoking:
    • 10,000,000,000,000,000 free radicals/cigarette!
  • Eating and Breathing: metabolism in your mitochondria
pharmanex research centers were involved
Pharmanex Research Centerswere involved…
  • Provo R&D Center
  • Shanghai R&D Center
  • Beijing R&D Center
years of searching
years of searching
  • Almost all failed Selection criteria
  • All but Four (g+3) very special fruits
g c fruit from heaven
Gâc -“Fruit From Heaven”
  • Indigenous to Southern Asia

Bangladesh, Burma, Cambodia, China, India, Japan, Laos, Malaysia, Philippines, Thailand, and Vietnam

  • Traditionally used internally and externally

Topical: wound healing

Internally: eye health, and to promote growth in children

slide41

Extraordinarily rich in antioxidants, esp. lycopene, beta-carotene, vitamin E

  • Unique fatty acids → Lipocarotenes™

Antioxidants in Gâc Pulp

Pulp

(aril)

Fruit flesh

(mesocarp)

Seeds

pharmanex research centers
Pharmanex Research Centers

3 Years of Searching and R&D

  • Gâc fruit (Chinese Bitter Cucumber)
  • Chinese Lycium (Wolfberry)
  • Cili fruit
  • Siberian Pineapple (Seabuckthorn)

3 +1 Superfruits

slide43

70 x more

than tomatoes!

Gac Fruit Lycopene Content

mcg/g wet weight

Ishida et al., J Agric Food Chem 52:274, 2004

slide44

10 x more

than carrots!

Gac Fruit Beta-CaroteneContent

mcg/g wet weight

Ishida et al., J Agric Food Chem 52:274, 2004

g c fights vitamin a deficiency
Gâc Fights Vitamin A Deficiency
  • …a Leading cause of blindness in the world
  • In So. Asia, Gâc discovered as potent indigenous source of highly bioactive provitamin A (b-carotene)
  • 10 years of research by Dr. Le Vuong, Univ. of California, Davis, Nutrition Department

*Vuong LT et al., Am J Clin Nutr 2002;75:872-879.

slide46
Zeaxanthin in Chinese Lycium Fruit

40 x more than

yellow corn!

mcg/g wet weight

slide47
Vitamin C in Cili Fruit

60 x more

than oranges!

mg/100g wet weight

lipocarotenes
Lipocarotenes™
  • Nature’s unique nutrient delivery system in
  • Gâc
    • contain fatty acids (unique among fruits)
    • with carotenoids & vitamin E pre-dissolved
    • Gâc carotenes: 40 % improved uptake*

*compared to beta-carotene powder. Vuong LT et al., Am J Clin Nutr 2002;75:872-879.

vulnerable to oxidation

Betacarotene

Lutein

Vitamin C

Lycopene

Vitamin E

Vulnerable to Oxidation
internal antioxidants

SOD

Catalase

Vitamin E

SOD

CAT

Internal Antioxidants
proprietary
Proprietary
  • Patent pending, 100%-juice formula
  • First juice with Gâc worldwide
  • Pharmanex bought world supply of Gâc & Cili(2004/2005 season)
slide52

will increase your scanner score!

  • 4,000 – 7,000 units @ 4 fl oz / day (8 weeks)
  • 12,000 – 20,000 units with LifePak®

Use to take LifePak®!

effect of and other juices on antioxidant status as measured by the biophotonic scanner

EFFECT OF AND OTHER JUICES ON ANTIOXIDANT STATUS AS MEASURED BY THE BIOPHOTONIC SCANNER

purpose
Purpose:
  • To compare the effects of, XanGo™ and Tahitian Noni® juices on antioxidant status
study design
Study Design
  • Subjects (N=34) were randomly assigned to 1 of 3 groups
  • Subjects consumed 3 fluid oz twice per day, with breakfast and with dinner for 8 weeks
  • Comparable Daily Intakes
    • 6 fl oz (Maximum recommended intake)
    • 6 fl oz Tahitian Noni® (6x’s Recommended dose)
    • 6 fl oz XanGo™ (2x’s Recommended dose)
increased antioxidant network scores 9 500 in 8 weeks

50,000

1

40,000

2

3

4

5

Antioxidant Network Score

30,000

6

7

8

9

10

20,000

11

10,000

Week 0

Week 8

Increased Antioxidant Network Scores ~9,500 in 8 Weeks
lipocarotenes in are more bioavailable

10,000

8,000

Antioxidant Score

6,000

4,000

2,000

g3Lipo-

carotenes

Other

Carotenes

0

Lipocarotenes™ in are More Bioavailable
slide58

10,000

#, *

Noni

XanGo™

g3

#, *

8,000

6,000

Antioxidant Score

#, *

4,000

*

2,000

0

Week 0

Week 2

Week 4

Week 6

Week 8

Increased Antioxidant Scores 4x’s More than XanGo™ or Noni

*p<0.05 compared to wk 0 #p<0.05 compared to other juices

conclusions
Conclusions†:
  • dramatically increases antioxidant scores.
  • Lipocarotenes™ in g3are 55% more easily absorbed.
  • has 4x’s the antioxidant potential of either XanGo™ or Tahitian Noni® Juice.

†Preliminary, unpublished data.

slide60

Thanks to

Angela Mastaloudis, Ph.D. Associate Senior Scientist

mark s business take aways
Mark’s Business Take-aways
  • Scanner Developed: was developed because of the scanner
  • SCS Certified: Guaranteed to Increase Antioxidant Score
  • Superfruit: A fruit that contains unusually high amounts of antioxidants
  • Lipocarotenes™: Natures unique delivery system
  • First to Market: Proprietary, Patent Pending, 100% Juice, World supply of Gâc and Cili
  • Tahitian Noni® & XanGo™ Lose: Noni and XanGo™ lose to g3 in scanner study
the power of nanotechnology

The Power of Nanotechnology

Carsten R. Smidt, Ph.D., FACN

Vice President, Global R&D

what is nanotechnology
What is Nanotechnology?

Example: Nano-Electronics

Nanotube Wires

Nano-Switch

a matter of size
A Matter of Size

Red Blood Cell

6000 nanometers

100 nanometers

what is nanotechnology65
What is Nanotechnology?
  • A Matter of Size: 1 -100 nanometers
    • Most molecules are 1 to 100 nm in size
  • Function at the Molecular Level
    • Nanotechnology is the science of manipulating substances at the molecular level
pharmanex nanotechnology
Pharmanex Nanotechnology
  • To increase intestinal uptake of poorly absorbed fat-soluble nutrients:
    • Carotenoids (lycopene, alpha+beta-carotenes, zeaxanthin, astaxanthin)
    • Coenzyme Q10
reasons for poor absorption
Reasons for Poor Absorption
  • Poor intestinal solubility
  • Requires fat for dissolution (e.g., Lipocarotenes)
  • Aggregation into large particles
    • not easily digested and absorbed
what is coq 10
What is CoQ10?
  • Coenzyme Q10, CoQ10, or ubiquinone
    • fat-soluble, vitamin-like nutrient that catalyzes energy production in cells*
    • found in all cell membranes, nuclei and mitochondria
    • produced in the body—decreasing with age

*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

coq 10 health benefits
CoQ10 Health Benefits*
  • Helps produce cellular energy, ATP
  • Provides powerful protection against free radical damage inside the cell (mitochondria)
  • Strengthens heart muscle - supports circulation
  • Maintains existing normal blood pressure
  • Skin health (anti-aging benefits)

*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

regular coq 10 products
Regular CoQ10 Products
  • Not easily absorbed into the body
  • High dose needed to achieve meaningful benefits
  • NanoCoQ10™ uses molecular nano-encapsulation to significantly improve absorption
slide73

CoQ10 Absorption by Human Intestinal Cells

300.0

5-fold increase in absorption!*

30 mg ≈ 150 mg

250.0

200.0

pmol/mg protein

150.0

100.0

50.0

0.0

Chewable A

Chewable B

Chewable C

CoQ10

Nano-CoQ10

powder

powder

*Preliminary, laboratory data

summary
Summary
  • Breakthrough nanotechnology
  • Highly bioavailable CoQ10
  • Heart protection*
  • Helps produce cellular energy*
  • Antioxidant protection*
  • Use with Celltrex® CoQ10 Complete
    • CoQ10 PowerPack
    • More at the Nu Skin workshop!

*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

slide76

Highly Effective

Minerals

Red Wine

Polyphenols

New

Vitamin E

Nano-CoQ10

Nano-

Nutrients

lifepak nano nano antioxidants78
lifepak®nano: Nano-Antioxidants
  • New, broader-spectrum nano-carotenoid formula:
    • alpha-carotene
    • beta-carotene
    • lycopene
    • lutein
    • zeaxanthin (new): Eye health benefits*
    • astaxanthin (new): Immune response*
  • plus LipoNutrients (proprietary process)

*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

lifepak nano omega 3 lipids
lifepak®nano: Omega-3 Lipids
  • Delivers MarineOmega benefits:
    • 600 mg EPA, 400 mg DHA
    • Antarctic Krill oil
  • Helps normalize omega 6/3 ratio in diet:
    • helps maintain normal inflammatory response*
    • promotes cardiovascular health*
    • supports brain & nervous system*

*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

lifepak nano vitamin e formula
lifepak®nano: Vitamin E Formula
  • Gamma-tocopherol:
    • synergistic antioxidant effects with alpha-tocopherol (neutralizes different free radicals)*
    • helps maintain normal inflammatory response*
  • New vitamin E formula in lifepak® nano:
    • 200 IU alpha-tocopherol (134 mg)
    • 75 mg gamma-tocopherol
    • 26 mg beta- and delta-tocopherols

= 235 mg total vitamin E (201 mg in LifePak® Prime)

*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

lifepak nano mineral sources
lifepak® nano: Mineral Sources
  • 600 mg Calcium, with new patented dicalcium malate (soluble, organic Ca)
  • 300 mg Magnesium, 100% amino acid chelate
  • Plus 6 other bone nutrients: D, K, P, B, Si, resveratrol*
  • Advantage: More efficient absorption and better GI tolerance than Ca and Mg in LifePak® Prime or LifePak® Women

*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

lifepak nano red wine actives
lifepak® nano: Red Wine Actives
  • “1-2 glasses of red wine a day keep the doctor away” (French Paradox)
  • Cardiovascular benefits attributed to red wine polyphenols:*
    • Resveratrol
    • Proanthocyanidins
    • Quercetin
  • lifepak® nano = 2 glasses red wine a day!

*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

new packet design
New Packet Design
  • Unique 2-chamber design
    • Separates soft-gels from hard shell capsules for optimum stability
    • New film with stronger protection and oxygen barrier (as in LifePak® Japan)

Phytonutrients

Minerals

Vitamins

proprietary

CR-6 LipoNutrients

new health benefits
New Health Benefits*
  • Helps maintain a healthy balance of pro- and anti-inflammatory signals (prostaglandins) in the body
    • Cardiovascular health (designed to lower C-reactive protein)
    • Joint health and mobility
  • Expanded cell rejuvenation & anti-aging benefits
    • CR6-LipoNutrients™, red wine benefits, 60+ antioxidants, incl. nano-antioxidants
  • Complete bone support (8 nutrients)
  • New eye health benefits (lutein & zeaxanthin)
  • Improved gastro-intestinal tolerance
  • plus the benefits of LifePak® Prime

*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

lifepak nano study

Better antioxidant response than LifePak®!

lifepak nano

lifepak® nano Study

60+ Antioxidants

Ongoing placebo-controlled clinical study

  • 57 subjects
  • 20 week study

LifePak

Placebo

slide86

Highly Effective

Minerals

Red Wine

Polyphenols

New

Vitamin E

Nano-CoQ10

Nano-

Nutrients

the power of nanotechnology91

The Power of Nanotechnology

Visit our PRODUCT SHOWCASE!

Win an iPod nano with lifepak® nano!

Purchase CoQ10 PowerPack and g3™!

carsten s business take aways
Carsten’s Business Take-aways
  • Nano Technology means increased absorption
  • CR6-LipoNutrients™ Technology is proprietary and patent-pending
  • Gentle to the stomach
  • Guaranteed to increase antioxidant score
  • Do You NANO?
now is the time
Now is the Time

“The FUTURE is literally in your hands and in the hands of the people you scan”

Joe Chang

be a champion 2005 workshop95
Be a Champion

2005 Workshop