Sepsis/Septic shock. Introduction. When bacteria is not effectively cleared by host defenses, a systemic inflammatory response is activated →sepsis. I ntroduction.
SIRS(systemic inflammatory response system)- cardinal signs are fever or hyothermia, leukocytosisor leukopenia, tachypnea,and tachycardia
Severe sepsis- when sepsis is associated with dysfunction of organs distant from the sight of infection
Septic shock- when hypotension cannot be corrected by infusing fluids
Harrisons 17th ed.
Alone or in combination, bacterial products and proinflammatory cytokines trigger physiologic responses to inhibit microbial invaders:
Shock- is a disruption in circulatory function leading to poor perfusion and inadequate delivery of oxygen and other nutrients to tissues
Early phase of sepsis:
Late phases of septic shock:
Neutropeniasign of overwhelming sepsis
For community acquired and nosocomial sepsis: 3rd generations cephalosporins (ceftriaxone, cefotaxime)
For fungal infections: amphotericin B