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Insulin Production

Insulin Production. Ultrafiltration Process Andrea Adams 1 April, 2004 CHEE 450. Unit Specifications – Givens. Insulin: 5700~5800 Da Polysulfone/Polyethersulfone membrane Rejection Coefficient 100% Concentrate Insulin x 10. Theory – Operation Principles.

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Insulin Production

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  1. Insulin Production Ultrafiltration Process Andrea Adams 1 April, 2004 CHEE 450

  2. Unit Specifications – Givens • Insulin: 5700~5800 Da • Polysulfone/Polyethersulfone membrane • Rejection Coefficient 100% • Concentrate Insulin x 10

  3. Theory – Operation Principles • Pressure driven membrane separation process • Membrane configuration is cross-flow Millipore

  4. Hardware Design Millipore

  5. Visuals 1890-3785 L/day 7570-15140 L/day Filtertech

  6. Membrane • Polysulfone • Produced in large quantities so tends to be cheaper • Polyethersulfone • PES theoretically has slight advantage over PS • More hydrophilic • Cellulose Acetate • Low chemical resistance; sensitivity to biodegradation • Difficult to clean; must be in constant presence of Cl

  7. Flows Perry’s

  8. Assumptions Made • Density of inlet stream similar to H2O • 1 batch/day • 24 h production cycle • 316 L mini-batches • Flux = 50 L.m-2.h-1

  9. Suppliers • Pollard Industries, LLC (Louisiana) • Ionics (Massachusetts) • Saborn Technologies (Massachusetts) • Berghof Filtration (Germany) • Applied Membranes (California) • Hydranautics (California) • inge AG (Illinois) • Koch Membrane Systems (USA) • Luxx Ultra-Tech • NORIT Membrane Technology BV (Netherlands) • PCI Membrane Systems Ltd. (UK) • Reverse Osmosis of South Florida (Florida) • Omexell, Inc. (Alabama) • Aquafilter, Inc. (Maryland) • Southwest Water Systems Co. (Oklahoma) • Uniexcel Agencies & Services Pvt. Ltd. (India) • Nilgiris Chemical Stoneware Company (India) • GEA Filtration (Wisconsin) • Culligan International Co. (Illinois)

  10. Design Considerations • Millipore process specification data entry • NMWL (kDa) • Width (cm) • Stack Design • Filtration Area (m2) • Height (cm) • Length (cm) • Filter Material • Configuration • Diameter (cm)

  11. Sizing • 316 L capacity • Max. operating pressure: 5 bar • Operating conditions: pH 1-14 • Dimensions: 97 x 48 x 89 cm • Weight: 580 kg • Fine Screen: 12-15 L.min-1 per 2.8 m2 cassette • Need 20 m2 filtration area, 7 cassettes • $147,800 Pall Corporation

  12. Process Alternatives • Spiral Wound oriented Ultrafiltration • Hollow Fiber oriented Ultrafiltration • Reverse Osmosis • Retains too much • Microfiltration • Retains too little • Diafiltration

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