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Suspected Hypersensitivity or Anaphylaxis

Suspected Hypersensitivity or Anaphylaxis. In all cases in which infusion reaction symptoms of any grade are observed, the infusion of cetuximab should be stopped. Measure vital signs

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Suspected Hypersensitivity or Anaphylaxis

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  1. Suspected Hypersensitivity or Anaphylaxis • In all cases in which infusion reaction symptoms of any grade are observed, the infusion of cetuximab should be stopped. • Measure vital signs • If a grade 3 or 4 infusion reaction is observed, the infusion of cetuximab should be discontinued immediately and should not be attempted again. • Appropriate medical therapy should be administered, which may include fluids,epinephrine, corticosteroids, diphenhydramine, bronchodilators, and oxygen. Thomas M, CLIN J ONC NURS 2005 ; 9:332

  2. Clinical signs, pathophysiology and management of skin toxicity during therapy with EGFR-I • untreated dermatological side-effects could represent a threat to patient compliance • acneiform eruptions respond well to topical anti-inflammatory acne therapy, tetracyclines are needed to treat moderate to severe cases. Segaert, Annals of Oncology 16: 1425–1433, 2005

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