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Primary Sclerosing Cholangitis (PSC). By: Andres Perez & Adriana Lopez. Primary Sclerosing Cholangitis (PSC). Is a disease in the digestive system where the Bile Ducts are blocked & damaged outside & inside the liver.

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Primary sclerosing cholangitis psc

Primary Sclerosing Cholangitis (PSC)

By: Andres Perez & Adriana Lopez

Primary sclerosing cholangitis psc1
Primary Sclerosing Cholangitis (PSC)

  • Is a disease in the digestive system where the Bile Ducts are blocked & damaged outside & inside the liver.

    • The Bile Ducts are the tubes that carry out the Bile from the liver into the Gallbladder and Small Intestine.

    • The Bile is the liquid which is made inside the liver & helps break down fat in foods.

Progression of psc
Progression of PSC

  • Inflammation of the Bile Ducts lead to scarring that narrows the bile ducts


  • The main symptoms of PSC are:

    • Itching of the Skin (may occur when toxins in bile get into the bloodstream)

    • Fatigue

    • Jaundice

    • Can cause chills and fever.

  • 6 out of 100,000 people

  • **Having family members with PSC may increase a person's risk of developing PSC.**

Advanced effects

  • As the disease progresses:

    • chronic fatigue

    • loss of appetite

    • weight loss

  • In the advanced stages, swelling can occur in the abdomen and feet. Liver failure may take many years to develop.

Complications of psc
Complications of PSC

  • Main complications that occur due to PSC include:

    • Deficiencies in Vitamins A, D, E, & K

    • Infections of the Bile Ducts

    • Cirrhosis-Extensive scarring of the liver

    • Liver Failure

    • Bile Duct Cancer

Causes of psc
Causes of PSC

  • The causes for PSC are not yet known.

    • Genetic

    • Immune System disorder

    • Bacteria

    • Virus


  • Treatment of PSC targets the relieving of symptoms and is meant to manage complications.

  • Medical treatment may include

    • Various medications to relieve itching

    • Antibiotics to treat infections

    • Vitamin supplements

    • Instruments

  • Liver transplantation may be an option if the liver begins to fail.


  • Blood tests to check levels of liver enzymes are the first step in diagnosing PSC.

  • Cholangiography can be performed in the following ways:

    • Endoscopic Retrograde Cholangiopancreatography (ERCP)

    • Percutaneous Trans Hepatic Cholangiography(PTHC)

    • Magnetic Resonance Cholangiopancreatography(MRCP)

    • Other testing may include ultrasound exams and a liver biopsy.

Effects of primary sclerosing cholangitis psc
Effects of Primary Sclerosing Cholangitis (PSC)

  • Deficiency of vitamin A, D, E and K

  • Liver Failure

  • Liver Cancer

  • Cirrhosis

  • Muscular and skeletal system malfunctions


  • 1) What is PSC?

    • A. A problem with your bladder

    • B. Scarring of the stomach

    • C. Scarring of the bile duct and liver

    • D. Painful digestion

  • 2) What are the causes of PSC?

    • A. Constant digestion of spicy foods

    • B. Being outside for more than 3 hours

    • C. Digestion of junk food

    • D. It is not yet known


  • 3) What are the 4 different vitamins that are affected in the body?

    • A. Vitamin A, D, E & K

    • B. Vitamins U, E, K, P

    • C. Vitamins B, C, T & D

    • D. Vitamins H, B, K, D

  • 4) What is one of the advanced effects of PSC?

    • A. Complications of the Pancreas

    • B. Hallucinations

    • C. Chronic Fatigue

    • D. Heartburn


Thank You

Vitamins a d e k
Vitamins A, D, E & K

Vitamin K:

Blood clot reducer

reduce risk of Osteoporosis

Reduces the threat of bleeding in liver

blood sugar regulator.

Vitamin D:

Calcium and Phosphorus Absorber

Arthritis Preventer

Blood Pressure Regulator

Tension and Stress Reducer

  • Vitamin A:

    • Antioxidant

    • Anti-Infection

    • Immunity Booster

  • Vitamin E:

    • Skin Protectant

    • Cancer Prevention

    • Metabolism Booster

    • Prevention of Alzheimer's.

Vitamin d deficiency
Vitamin D Deficiency

  • Vitamin D is one of four vitamins that lacks presence in the body; without Vitamin D in the body problems in the Skeletal & Muscular System could begin to develop.

Skeletal system
Skeletal System

Low Levels of Ca2+

  • 1.Blood circulates through Parathyroid Gland, Ca2+below “set point” is detected.

  • 2.Parathyroid Gland releases Parathyroid Hormone(PTH) and PTH travels through blood.

  • 3.PTH travels through Haversian Canal to stimulate osteoclasts to work and break down the bone to release Ca2+ in the blood.

  • 4.Kidneys release Vitamin D to the small intestine and more Ca2+ is absorbed from digested foods(more Ca2+ in blood).

  • 5.Kidneys are also signaled to not release Ca2+ in urine which causes more Ca2+ in the blood.

Muscular system
Muscular System

Steps to Muscle Contraction:

  • 1.Brain sends nerve signals to the skeletal muscle releasing Aretylcholine to muscles, Ach then causes Ca2+ to be released to muscles.

  • 2.Ca2+ then binds to troponin, causing a change in shape, Tropomyosin then changes shape, rotating and revealing Actin binding site.

  • 3.This allows myosin to bind to Actin and pull Actin. ATP then releases Actin/Myosin so Myosin can bind to another Actin and this repeats.

  • 4. Ca2+ is then released from Troponin causing all molecules to go back to its original shape. Then Myosin cannot bind to Actin so the muscle is relaxed.

Works cited
Works Cited