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Functional Optical Imaging of Brain

Various Uses of Optical Imaging. Blood Deoxygenation. Blood Volume. Suspicious area. Telemedicine. Remote Environments. Co-registration of fMRI with fNIR. Functional brain activity monitor. Cancerous Area. Blood Deoxygenation. Blood Volume. Non-Cancerous Area. Pad.

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Functional Optical Imaging of Brain

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  1. Various Uses of Optical Imaging Blood Deoxygenation Blood Volume Suspicious area Telemedicine Remote Environments Co-registration of fMRI with fNIR Functional brain activity monitor Cancerous Area Blood Deoxygenation Blood Volume Non-Cancerous Area Pad Functional Near-Infrared Imaging of Breast BIOMEDICAL OPTICS RESEARCH P R O G R A M O V E R V I E W The maturing technologies of functional optical imaging of the brain using near infrared (NIR) are poised for broad-based deployment in military, civilian, educational, and health care applications. These applications range from alertness/vigilance monitoring and mental disorder assessment to the evaluation of cognitive engagement. This safe, affordable, portable, non-invasive, and non-intrusive technology can be used in high stress, high responsibility environments, as well as in health care and academic settings. Functional Optical Imaging of Brain Functional Optical Imaging of Breast Recent advancements in functional optical imaging of biological tissues using near infrared (NIR) have reached a level where a much broader based delivery of health care can be realized with this novel modality. Its potential use as a prescreening diagnostic tool for early detection of breast cancer offers an important complement to existing screening instruments that are too expensive and/or immobile. In particular, this safe, affordable, portable, and non-invasive technology makes a much-needed diagnostic tool available to underserved segments of the population. Institutional Collaborators / Primary Contacts: Dr. Banu Onaral, Drexel University (PA); Dr. Kambiz Pourrezaei, Drexel University (PA); Dr. Scott Bunce, MCP Hahnemann University (PA); Dr.Britton Chance, University of Pennsylvania (PA); Dr. Joseph Kolodzey, University of Delaware (DE); Dr. Robi Polikar, Rowan University (NJ); Dr. Kamelia Alavi, Technology & Medicine, Inc. (PA); Dr. Harel Rosen, St. Peter’s Hospital (NJ); Dr. Warren S. Warren, Princeton University (NJ); Dr. Arye Rosen, Sarnoff Corporation (NJ); Dr. Joseph Elad, Quantum Leap Innovations, Inc. (DE); Dr. Mike Contarino, NAVAIR (MD); Mr. James Buss, Office of Naval Research (VA); Dr. Joseph H. Ricker, Kessler Institute of Rehabilitation (NJ).

  2. Various Uses of Optical Imaging Antenna DSP SoC Flex Circuits Batteries EEG Electrode fNIR optodes • Pilot Training/Monitoring • Truck Driver Monitoring Telemedicine Remote Environments Functional brain activity monitor Co-registration of fMRI with fNIR Brain images illustrating the progress of learning during a linguistic task; after a task is learned, the student uses a small region of the brain more efficiently. FUNCTIONAL OPTICAL IMAGING OF BRAIN P R O J E C T O N E P A G E R The maturing technologies of functional optical imaging of the brain using near infrared (NIR) are poised for broad-based deployment in military, civilian, educational, and health care applications. These applications range from alertness/vigilance monitoring and mental disorder assessment to the evaluation of cognitive engagement. This safe, affordable, portable, non-invasive, and non-intrusive technology can be used in high stress, high responsibility environments, as well as in health care and academic settings. • Military Impact • Monitoring pilots’ state of alertness/vigilance. • Detection of sleep deprivation and its effect on soldier performance. • Design of more effective customized training protocols. • Healthcare Impact • Monitoring brain function in neonates and geriatric patients. • The possibility of a non-invasive, non-intrusive, and affordable brain imaging system. • Investigation of mental disorders and monitoring success of treatment. • Educational Impact • Brain mapping during learning, memory, and cognitive tasks. • Customization of instructional methodology to individual learning styles. • Economic Impact • The functional optical imaging technology platform will be the basis of new products for military, healthcare, and educational use. Institutional Collaborators / Primary Contacts: Dr. Banu Onaral, Drexel University (PA); Dr. Kambiz Pourrezaei, Drexel University (PA); Dr.Britton Chance, University of Pennsylvania (PA); Dr. Scott Bunce, MCP Hahnemann University (PA); Dr. Joseph Kolodzey, University of Delaware (DE); Dr. Robi Polikar, Rowan University (NJ); Dr. Kamelia Alavi, Technology & Medicine, Inc. (PA); Dr. Harel Rosen, St. Peter’s Hospital (NJ); Dr. Warren S. Warren, Princeton University (NJ); Dr. Arye Rosen, Sarnoff Corporation (NJ); Dr. Joseph Elad, Quantum Leap Innovations, Inc. (DE); Dr. Mike Contarino, NAVAIR (MD); Mr. James Buss, Office of Naval Research (VA); Dr. Joseph H. Ricker, Kessler Institute of Rehabilitation (NJ).

  3. Various Uses of Optical Imaging Blood Deoxygenation Blood Volume Suspicious area Telemedicine Remote Environments Cancerous Area Blood Deoxygenation Blood Volume Non-Cancerous Area Pad Functional Near-Infrared Imaging of Breast FUNCTIONAL OPTICAL IMAGING OF BREAST P R O J E C T O N E P A G E R Recent advancements in functional optical imaging of biological tissues using near infrared (NIR) have reached a level where a much broader based delivery of health care can be realized with this novel modality. Its potential use as a prescreening diagnostic tool for early detection of breast cancer offers an important complement to existing screening instruments that are too expensive and/or immobile. In particular, this safe, affordable, portable, and non-invasive technology makes a much-needed diagnostic tool available to underserved segments of the population. • Economic Impact •  Development of novel optical medical imaging equipment is of critical economic value to the nation. • Regional Impact • Use of a new medical imaging system will enhance the prestige of regional medical centers and development of new products, along with related job opportunities. • Societal Impact • The possibility of non-invasive and affordable breast imaging can have a significant impact on early detection of breast cancer in underserved populations. • Military Impact • A portable, non-invasive, inexpensive, robust, and compact medical imaging and diagnostics tool for use in telemedicine is of paramount importance for identifying hemorrhage in the battlefield. Design of a portable handheld NIR Breast Cancer Imager Institutional Collaborators / Primary Contacts: Dr. Banu Onaral, Drexel University (PA); Dr. Kambiz Pourrezaei, Drexel University (PA): Dr.Britton Chance, University of Pennsylvania (PA); Dr. Joseph Kolodzey, University of Delaware (DE);Dr. Warren S. Warren, Princeton University (NJ); Mr. James Buss, Office of Naval Research (VA); Dr. Mike Contarino, NAVAIR (MD).

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