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Iowa gambling task (rats) anxiety and the medial prefrontal cortex. de Visser, Baars , van t’ Klooster , van den Bos. Net = -$2,500. Net = -$2,500. Over 100 trials. Net = $2,500. Net = $2,500. Why would you make a disadvantageous choice?.

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iowa gambling task rats anxiety and the medial prefrontal cortex

Iowa gambling task (rats) anxiety and the medial prefrontal cortex

de Visser, Baars, van t’ Klooster, van den Bos

slide2

Net = -$2,500

Net = -$2,500

Over 100 trials

Net = $2,500

Net = $2,500

why would you make a disadvantageous choice
Why would you make a disadvantageous choice?
  • People with a “broken” medial Prefrontal Cortex (mPFC)
    • Emotional control and conflict resolution
      • Decision making in short…
    • Malfunction = bad decisions
slide4
mPFC
  • In rats: mPFC involved in anxiety & decisions
  • May be impaired in people with high anxiety
things you are allowed to do with rats and not humans
Things you are allowed to do with rats and not humans…
  • Artificially deactivate mPFC
    • Inject GABA agonists
      • GABA receptor A - muscimol
      • GABA receptor B - baclofen
anxiety
Anxiety

-Inactivation of mPFC INCREASES anxiety

slide7

“Good”

choice

“Bad”

choice

Nothing

slide8

Nothing

1 pellets:

20% quinine

80% sucrose

“Good”

choice

3 pellets:

90% quinine

10% sucrose

“Bad”

choice

slide9

5 days testing

2 days rest

4 days testing

1

2

3

4

5

6

7’

8’

9’

20 trials / day

I.C. injection each day

10 trials / day

slide11

Trials 41-60

All animals included

Median = x

“Good performer” = >x

“Bad performer” = <x

slide12

???Base line values of what???

  • The entire population (good and bad; trial 41-60)?
  • The respective “good” and “bad” population; trial 41-60?
  • The individual only; trial 41-60?
slide15

Trials 1-60

Trials 61-120

Exploration

Defined strategy

mPFC

Amygdala & ventral striatum

Van Den Bos 2007

slide16

Defined strategy

mPFC

Exploration

Amygdala & ventral striatum

what is this experiment
What is this experiment?

Inactivation of mPFC increases anxiety

Increased anxiety

Poor decision making

????

slide18

Current paper

Anxiety / fear

mPFC

Koot poster

HPA axis

Corticosteroids

susanne koot s poster
Susanne Koot’s poster

Corticosterone

(stress in a needle)

slide23

Net = -$2,500

Net = -$2,500

Over 100 trials

Net = $2,500

Net = $2,500