Thus, as already said, the greater the flow of food and the greater this amount, the more likely will be the inverse relationship of enzyme concentration and substrate concentration, hindering the digestion. In fact, some time ago I discovered that, in practice made much difference to interfere directly in the results. With supplement manager a next 6000Kcal diet, weight loss was increasingly frequent. The feeling more crowded stomach every meal was depressing and limiting factor for food intake. It was really hell, to tell the truth. Examinations were made and nothing about diabetes or lack of insulin, was positive.