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合成盐酸普鲁卡因的纯度检查 PowerPoint Presentation
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合成盐酸普鲁卡因的纯度检查 - PowerPoint PPT Presentation


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合成盐酸普鲁卡因的纯度检查. 谢岑 杨优 沈红霞 魏丽丽 李新 黄鹏 刘守志 袁敏莉 田野 王成 钱钟书 戴伟东. 药物介绍. 盐酸普鲁卡因 化学名为 4- 氨基苯甲酸 -2-( 二乙氨基 ) 乙酯盐酸盐,属于 芳酸酯类 局麻药。 麻醉强度强,毒性小约、穿透力强、作用迅速、持久,临床上用于浸润麻醉,硬膜外麻醉和阻滞麻醉。. 杂 质来源之一, 酯化不完全的对硝基苯甲酸经还原产生 PABA. 药化合成路线. 直接酯化法. 合成过程原料残留,反应进行不充分,生成各种杂质. procaine 水解产生 PABA. 主要杂质 —— 对氨基苯甲酸.

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