Partial Breast Irradiation . Carol Marquez, M.D. Associate Professor, Department of Radiation Medicine Oregon Health and Sciences University. Goals of discussion. Discuss the changing epidemiology of breast cancer Present the data supporting breast preservation therapy (BPT)
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Carol Marquez, M.D.
Department of Radiation Medicine
Oregon Health and Sciences University
The good news: Mortality declined by 2% per year from 1990 to 2001, with the greatest declines in women younger than 50 years. Estimated deaths in 2007 = 40,910.
The bad news: An estimated 180,510 new cases will be diagnosed in 2007. The incidence has continued to gradually increase since 1990.
Recent decline in ER + breast cancer incidence may be secondary to 40% decline in use of hormone replacement therapy between 2000- 2003.
SEER Age-Adjusted Incidence Rate ComparisonFor Breast CancerSEER 9 Registries for 1975-2004
IBTR= In breast tumor recurrence
Disease-free Survival (Panel A), Distant-Disease-free Survival (Panel B), and Overall Survival (Panel C) among 589 Women Treated with Total Mastectomy, 634 Treated with Lumpectomy Alone, and 628 Treated with Lumpectomy plus Irradiation
Fisher, B. et al. N Engl J Med 2002;347:1233-1241
Revised Consensus Statement for Accelerated Partial Breast Irradiation, 12/8/05