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SITOKIN. Sekresi protein yang menjembatani dan mengatur sistem imun, inflamasi dan hematopoiesis Sitokin diproduksi sebagai respon stimulus dari proses imunitas Sitokin biasanya bekerja dalam waktu yang singkat, jarak antar sel yg dekat, dan dalam jumlah (konsentrasi) yang sangat kecil

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sitokin

SITOKIN

Sekresi protein yang menjembatani dan mengatur sistem imun, inflamasi dan hematopoiesis

Sitokin diproduksi sebagai respon stimulus dari proses imunitas

Sitokin biasanya bekerja dalam waktu yang singkat, jarak antar sel yg dekat, dan dalam jumlah (konsentrasi) yang sangat kecil

Sitokin bekerja dengan melekat pada membran reseptor yg spesifik, kemudian memberi signal pd sel melalui messenger kedua (sering terjadi enzim tyrosinkinase merusak kejadian tersebut)

sekresi sitokin oleh
Sekresi sitokin oleh:
  • Limfosit limfokin
  • Monosit monokin
  • Sitosin yg aktif dlm khemotaktik khemokin
  • Sebagai media antar leukosit interleukin(IL)

Reseptor sitokin

sitokin1
Sitokin
  • Tidak seperti hormon yg tersimpan dalam kelenjar(dlm btk molekul), sitokin cepat disintesis dan disekresikan oleh sel yg berbeda setelah ada stimulus

Sitokin

aktivitas sitokin
Aktivitas sitokin
  • Berefek thdp sel yg mensekresinya sendiri autokrin
  • Berefek thdp sel didekatnya parakrin
  • Berefek pada sel yg sama tp berjauhan endokrin
  • Produser sitokin paling banyak adalah: sel –Th dan makrofag
efek sitokin
Efek sitokin
  • Pleiotropism
  • Redunden
  • Sinergik
  • Antagonis
  • Membentuk network sitokin
pleiotropism
Pleiotropism
  • Kemampuan satu sitokin untuk dapat menyebabkan multiplikasi dari tipe sel target
redunden
Redunden
  • Multipel sitokin mempunyai efek yg sama atau overlaping
sinergik
Sinergik
  • Dua atau lebih sitokin mempunyai efek saling menguatkan
antagonisme
Antagonisme
  • Kemampuan satu sitokin untuk menghambat aksi sitokin lainnya
klasifikasi sitokin
Klasifikasi sitokin
  • Interleukin, IL
  • Interferon , IFN
  • Tumor necrosis factor, TNF
  • Colony stimulating factor, CSF
  • Chemokine
  • Transforming growth factor
interleukin il
Ⅰ. Interleukin (IL)
  • Sitokin yg disekresi oleh leukosit yg mampu memberi tanda /menjembatani aktivitas leukosit lainnya
  • IL-1~IL-29
interferon ifn
Ⅱ. Interferon (IFN)

A group of glycoproteins that produced by human or animal cells following the infection of virus and exposure to various inducing agents

comparison of ifn ifn ifn
Comparison of IFN-, IFN-, IFN-

_____________________________________

Types Produced cells Main functions

____________________________________

IFN- leukocyte anti-virus,immune regulation

IFN- fibroblast anti-tumor

IFN---Type II Th1,NK ------- weaker anti-virus effect

stronger immune regulation effect

anti-tumor

_____________________________________

Type I

tumor necrosis factor tnf
Ⅲ.Tumor necrosis factor (TNF)

TNFs were originally thought of as selective antitumour agents, but are now known to have a multiplicity of actions.

  • TNF- is produced mainly by LPS activated monocytes and macrophages.
  • TNF-(lymphotoxin, LT) is produced mainly by activated Th0 and Th1.
colony stimulating factors csf
Ⅳ. Colony-stimulating factors (CSF)

Cytokines that stimulate proliferation or differentiation of pluripotent hematopoietic stem cell and different progenitors.

  • Multi-CSF (IL-3)
  • Granulocyte macrophage-CSF(GM-CSF)
  • Monocyte-CSF(M-CSF)
  • Granulocyte-CSF(G-CSF)
  • Stem cell factor(SCF)
  • Erythropoietin(EPO)
chemokine
Ⅴ. Chemokine

Chemokines are cytokines which recruiting monocytes,granulocytes and lymphocytes in blood to the sites of inflammation.

  • CXC chemokines(α subgroup):IL-8
  • CC chemokines(β subgroup):MCP-1
  • C chemokines(γ subgroup)
  • CX3C chemokines(δ subgroup)

*C: cysteine; X: any amino acid

transforming growth factor
Ⅵ. Transforming growth factor

Growth-factor are cytokines which stimulate the growth of their target cells.

  • Transforming growth factor-(TGF- )
  • Epithelia growth factor(EGF)
  • Vascular endothelia cell growth factor(VEGF)
  • Fibroblastic growth factor(FGF)
part ck receptor
PartⅢ CK receptor

1. Membrane-binding cytokine receptors:

The receptor consists of extra-cellular region, trans-membrane region and cytoplastic region.

slide24
CK receptors can be grouped into five families according to structure and function:

(1) Ig receptor superfamily:IL-1R,PDGFR,FGFR

(2) Type Ⅰ CK receptor superfamily: CSFR

(3) Type Ⅱ CK receptor superfamily: IFNR

(4) Type Ⅲ CK receptor superfamily: TNFR

(5) G-protein linked receptor superfamily: CCR5

slide26
Low affinity IL-2R

Moderate affinity IL-2R

High affinity IL-2R

IL-2

g

g

a

a

b

b

IL-2 receptor

part biological functions of cytokines
PartⅣ Biological functions of cytokines

1.Take part in nonspecific immunity ------anti-bacteria, anti-virus

2. Take part in specific immunity

3. Stimulate hematopoiesis

4. Take part in inflammatory reaction

part cytokine and disease
PartⅤ Cytokine and disease
  • Cytokines and diagnosis: IL-3, CSF
  • Cytokines and treatment: Th1 and Th2
  • Cytokines and disease prevention: CSF, IL-2
  • Cytokine assay
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