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DNAk = HSP70

DNAk = HSP70. Anfinsen Cage. 1-2) SRP binds leader peptide (pausing translation), which will take it to the proper location 3) Once in place SRP falls off and the ribosome continues to translate protein 4) A peptidase cleaves the leader peptide and then BIP

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DNAk = HSP70

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  1. DNAk = HSP70

  2. Anfinsen Cage

  3. 1-2) SRP binds leader peptide (pausing translation), which will take it to the proper location • 3) Once in place SRP falls off and the ribosome • continues to translate protein • 4) A peptidase cleaves the leader peptide and then BIP • (an HSP70 like protein) binds to facilitate proper folding. “Leader peptide” 5) Dissociation of complex

  4. Nobel Prize 2004 Cancer treatment Targeting the proteasome Ubiquitin tagging

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