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Healing and Gangrene

Healing and Gangrene

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Healing and Gangrene

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  1. Healing and Gangrene

  2. Gangrene: • It’s a necrosis with putrefaction,. • It has 3 types: • 1- Dry or senile gangrene. Gradual arterial occlusion usually affect the extremities • 2- Moist gangrene. Sudden arterial and venous occlusion, Bacterial invasion , skin is black, moist and of foul odour • 3- Gas gangrene. Due to infection with gas producing organism

  3. 1- Dry gangrene “Gross”: Dry gangrene: Gradual arterial occlusion, usually affect the extremities. The skin is dark brown or black and dry. There is a line of demarcation between the gangrenous area and the healthy tissues. e.g. senile gangrene of the lower limb

  4. Healing: • Replacement of damaged tissue by new, healthy, living tissue. • Either by: 1- Regeneration mechanism : Replacement of damaged cells by new cells of the same kind 2- Scaring “fibrosis”: is the replacement of tissue by Granulation tissue which matures to fibrous tissue.

  5. 2- Granulation tissue: The damage area is invaded by granulation tissue that consist of: new capillaries form, spindle shaped fibroblasts, Homogenous pale pink ground substance showing few pink collagen fibers and and inflammatory cells .

  6. 3- Granulation tissue:

  7. 4- Primary union of wounds: Blood clot formation at the site of wound. Phagocytic cells  remove debris. Granulation tissues  fibrous tissues  scar. Epithelium regenerate and move toward the center

  8. 5- Secondary union of wounds : Large tissue defect More inflammation More granulation tissue

  9. 6- Myocardial scaring: Scar tissue appearing between cardiac muscles, it is appears homogenous, pink in color and new capillaries and fibroblast formed

  10. 7- Repair after myocardial infarction: -the infarct area shows loss of details of the muscle fibers, the necrotic muscle fibers appear granular and pink with blue nuclear fragments.