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Understanding Virus Replication and Bacterial Growth Dynamics

This lecture delves into the intricacies of virus replication, highlighting key phases such as the latent period and the eclipse period. It contrasts viral growth with bacterial reproduction, emphasizing binary fission. The discussion includes the timeline of virus progeny release and the critical processes during the eclipse phase, such as early and late protein synthesis and genome replication. Furthermore, it examines how viral genomes are safeguarded against degradation and damage, showcasing the role of condensation and protein association in genome protection.

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Understanding Virus Replication and Bacterial Growth Dynamics

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  1. MICR. 402 Lecture 5 January 17, 2008

  2. Chapter 2 - Virus Replication Bacterial growth - binary fission

  3. Chapter 2 - Virus Replication One step growth curve Latent period time until progeny virus released from infected cells - don't confuse with latency of herpes viruses Eclipse period time when no complete virus inside cells - infectivity = nil if disrupt infected cells

  4. Chapter 2 - Virus Replication What’s happening during eclipse and latent phases? Early protein synthesis Replication of genome Late protein synthesis Assembly of virions Release

  5. Chapter 3 - Genomes Use chapter as reference.

  6. Chapter 4 - Virus Structure

  7. Chapter 4 - Virus Structure

  8. How are genomes protected? - Genomes need to be protected from degradation by RNAses, DNAse, or restriction enzymes, or damage by UV radiation. - Condensation protects against RNAses, DNAse, and also association with proteins is key in protecting the genome.

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