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I

Supplementary Figure e-1.Grey matter atrophy of patients compared to controls. Voxel-based morphometry analysis showing brain area atrophy for i) ALS vs. controls, ii) ALS-FTD vs. controls, iii) ALS vs. ALS-FTD and iv) ALS-FTD vs. ALS. Clusters are overlaid on the MNI standard brain (t>2.41). Coloured voxels show regions that were significant in the analyses for p<0.05 FWE corrected, except for ALS vs. controls and the ALS vs. ALS-FTD contrasts which was thresholded at p<.001, FDR corrected, and a cluster threshold of 50 contiguous voxels.

z = 60

x = 0

x = -60

i)

ii)

x = 8

x = -38

z = 46

iii)

z = -46

x = -4

iv)

x = 38

z = -42

x = -12


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