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Current Management of Diabetes. Introduction to Primary Care: a course of the Center of Post Graduate Studies i n FM. PO Box 27121 – Riyadh 11417 Tel: 4912326 – Fax: 4970847. Aim. having information on assessing symptoms and signs. developing management plans for diabetes. Objectives.
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Current Management of Diabetes Introduction to Primary Care: a course of the Center of Post Graduate Studies in FM PO Box 27121 – Riyadh 11417 Tel: 4912326 – Fax: 4970847
Aim • having information on assessing symptoms and signs. • developing management plans for diabetes.
Objectives At the end of this session, the trainees should be able to:- • list diagnostic criteria for DM • describe how to differentiate Type I & II DM • explain symptoms and signs of diabetes • discuss the evidence for lifestyle changes • describe the indications, contraindications, and side effects of antidiabetic agents
DM in Saudi Arabia Lifestyle Changes : Social & cultural changes Prevalence : • Diabetes mellitus as a health problem in Saudi Arabia • prevalence of DM is 23.7 % according to Dr. Al Nozha study (SMJ 2004) • 1 / 4 of adults > 30 yr are diabetics. • 36 Foot Amputation / day, at Riyadh.
D.M in Saudi Arabia cont….. Cost & Impacts . • Psychological impact. • Family & Social impact . • Decreased Productivity . • Sick leaves. • Work Absence . • Economical Costs .
Etiologic classification of diabetes mellitus I- Type 1 diabetes: II- Type 2 diabetes. III- Other specific types. IV- Gestational diabetes mellitus.
Etiologic Classification of Diabetes Mellitus • Type 1: • b-cell destruction with lack of insulin . • has absolute insulin deficiency • predisposed to develop ketoacidosis • insulin is required for survival.
Etiologic Classification of Diabetes Mellitus • Type 2 • has relative insulin deficiency combined with defects in insulin action. • is the most common form of diabetes, accounting for 90–95% of the disease • is most often found in overweight individuals. Narayan K, Boyle J, Thompson T, Sorensen S, Williamson D (2003). "Lifetime risk for diabetes mellitus in the United States". JAMA 290 (14): 1884–90. doi:10.1001/jama.290.14.1884.
Risk Factors for Type 2 DM • Non- Modifiable • Family history • Age • Gender • History of GDM • Polycystic ovary syndrome (PCO) • Modifiable • Overweight and obesity • Sedentary lifestyle • Previously identified IGT and IFG • Metabolic syndrome • Diatery factors • Intrauterine environment • Inflamation
Symptoms & Signs • Classical symptoms • Unusual thirst (Polydipsia) • Frequent urination (Polyuria) • Unusual weight loss • Other symptoms • Extreme fatigue or lack of energy • Unusually hungry • Moody & irritable • Blurred vision • Have recurrent infections • Wounds and bruises that are slow to heal • Get a lot of yeast infections • Have tingling or numbness in the hands and/or feet • Patients may present with a variety of symptoms or even symptomless
Criteria to diagnosis diabetes • FPG >126 mg/dl (7.0 mmol/l) (Fasting is defined as no caloric intake for at least 8 h)OR • Symptoms of diabetes and a casual plasma glucose > 200 mg/dl (11.1 mmol/l) OR • 2-h plasma glucose >200 mg/dl (11.1 mmol/l) during an OGTT. (The test should be performed as described by theW H O (using a glucose load containing the equivalent of 75g anhydrous glucose dissolved in water)).
Diagnosis of Diabetes :Plasma Glucose Cutoff Points * If without symptoms, there should be more than one measurement in order to diagnose. .
First visit evaluation History taking and clinical assessment Physical examination • Height and weight measurement . • Blood pressure determination . • Fundoscopic examination • Oral examination • Thyroid palpation • Cardiac examination
First visit evaluation Physical examination • Abdominal examination (e.g., for hepatomegaly) • Evaluation of pulses by palpation • Hand/finger examination • Foot examination • Skin examination • Neurological examination • Signs of diseases that can cause secondary diabetes (e.g., hemochromatosis, pancreatic disease)
First visit evaluation Laboratory evaluation • HBA1c • Fasting lipid profile • Test for microalbuminuria • Serum creatinine in adults . • Thyroid-stimulating hormone (if indicated) • Electrocardiogram in adults (if indicated) • Urinalysis for ketones and protein
Management Goals • Annual visits and examinations should be done regularly • Eliminate symptoms and improve well-being • Prevent and retard microvascularcomplications • optimize glycemic control • target blood pressure levels • Reduce macrovascular events • optimize glycemiccontrol • target blood pressure levels • target lipid levels
Summary of recommendations for adults with Diabetes Parameter Target Value • HbA1c< 7% • pre-prandial plasma glucose 70 -130 mg/dL • post-prandial plasma glucose < 180 mg/dL • Blood pressure < 130/80 mmHg • LDL- cholesterol < 100 mg/dL (<2.6 mmol/l) • HDL- cholesterol > 40 mg/dL (1 mmol/l) for men> 50 mg/dL (1.3 mmol/l) for wom. • Triglycerides < 150 mg/dL (17 mmol/l) ADA 2009
Key concepts in setting glycemic goals Goals should be individualized based on: ● duration of diabetes ● pregnancy status ● age ● co-morbid conditions ● hypoglycemia unawareness ● individual patient considerations
Things to keep in mind during management of Diabetes • Type 2: Deterioration of beta cells over time • Increasing prevalence with increasing risk factors, e.g obesity • Hyperglycemia affects morbidity, mortality and resources • Tight glycemic control with insulin may reduce costly complications • 30% to 40% of patients ultimately require insulin
Non-pharmacologic Therapy for DMLifestyle therapeutic modifications • Diet • Improved food choices • Spacing meals • Individualized carbohydrate content • Moderate calorie restriction • Exercise • improve blood glucose control • reduce cardiovascular risk factors • contribute to weight loss. • improve well-being.
Nutritional recommendations for DM patients • Protein to provide 10-20% of kcal/day • Saturated fat to provide < 10% of kcal/day (< 7 % for those with elevated LDL). • Polyunsaturated fat to provide < 10 % of kcal. • Remaining calories to be divided between carbohydrate & monounsaturated fat, based on medical needs & personal tolerance. • Use of caloric sweeteners is acceptable.
Considerations in Pharmacologic Treatment of Diabetes • Complications/tolerability • Frequency of hypoglycemia • Compliance/complexity of regimen • Cost