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Aging Brain: Molecular Chaperones to the Rescue

Aging Brain: Molecular Chaperones to the Rescue. Evgeny Nudler Julie Wilson Anderson Professor of Biochemistry NYU Langone Medical Center. Molecular Chaperones Assist Protein Folding and Prevent Toxic Aggregation. folded functional protein. chaperones. Patients with

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Aging Brain: Molecular Chaperones to the Rescue

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  1. Aging Brain: Molecular Chaperones to the Rescue Evgeny Nudler Julie Wilson Anderson Professor of Biochemistry NYU Langone Medical Center

  2. Molecular Chaperones Assist Protein Folding and Prevent Toxic Aggregation folded functional protein chaperones Patients with Alzheimer’s disease Toxic aggregates and amyloid fibrils plaques unfolded protein tangles

  3. Chaperones are the Heat Shock Proteins (HSPs) Chaperones = HSPs Neurodegenerative diseases: Alzheimer’s (AD) Parkinson’s (PD) Huntington's (HD) Amyotrophic Lateral Sclerosis (ALS) etc.

  4. Future Medicines for Aging Neurons: Chaperone-based Approaches Approach #1: Activation of cellular chaperones (HSPs) without stress Neurodegeneration HSPs activators HSPs

  5. Future Medicines for Aging Neurons: Chaperone-based Approaches Approach #2: Treatment with exogenous chaperones (e.g. Hsp70) Alzheimer’s disease Hsp70

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